CONTEXT: Community-acquired methicillin-resistant Staphylococcus aureus (MRSA) is becoming more prevalent in healthy athletic populations. Various preventive measures have been proposed, but few researchers have evaluated the protective effects of a prophylactic application of a commercially available product. OBJECTIVE: To compare the persistent antimicrobial properties of a commercially available antimicrobial product containing 4% chlorhexidine gluconate (Hibiclens) with those of a mild, nonmedicated soap (Dr. Bronner's Magic Soap). DESIGN: Cross-sectional study. SETTING: Microbiology laboratory, contract research organization. PATIENTS OR OTHER PARTICIPANTS: Twenty healthy human volunteers. INTERVENTION(S): The test and control products were randomly assigned and applied to both forearms of each participant. Each forearm was washed for 2 minutes with the test or control product, rinsed, and dried. At, 1, 2, and 4 hours after application, each forearm was exposed to MRSA for approximately 30 minutes. MAIN OUTCOME MEASURE(S): Differences in numbers of MRSA recovered from each forearm, test and control, at each post-application time point were compared. RESULTS: Fewer MRSA (P < .0001) were recovered from the forearms treated with the test product (4% chlorhexidine gluconate) than from the forearms treated with the control product (nonmedicated soap). CONCLUSIONS: The 4% chlorhexidine gluconate product demonstrated persistent bactericidal activity versus MRSA for up to 4 hours after application.
RCT Entities:
CONTEXT: Community-acquired methicillin-resistant Staphylococcus aureus (MRSA) is becoming more prevalent in healthy athletic populations. Various preventive measures have been proposed, but few researchers have evaluated the protective effects of a prophylactic application of a commercially available product. OBJECTIVE: To compare the persistent antimicrobial properties of a commercially available antimicrobial product containing 4% chlorhexidine gluconate (Hibiclens) with those of a mild, nonmedicated soap (Dr. Bronner's Magic Soap). DESIGN: Cross-sectional study. SETTING: Microbiology laboratory, contract research organization. PATIENTS OR OTHER PARTICIPANTS: Twenty healthy human volunteers. INTERVENTION(S): The test and control products were randomly assigned and applied to both forearms of each participant. Each forearm was washed for 2 minutes with the test or control product, rinsed, and dried. At, 1, 2, and 4 hours after application, each forearm was exposed to MRSA for approximately 30 minutes. MAIN OUTCOME MEASURE(S): Differences in numbers of MRSA recovered from each forearm, test and control, at each post-application time point were compared. RESULTS: Fewer MRSA (P < .0001) were recovered from the forearms treated with the test product (4% chlorhexidine gluconate) than from the forearms treated with the control product (nonmedicated soap). CONCLUSIONS: The 4% chlorhexidine gluconate product demonstrated persistent bactericidal activity versus MRSA for up to 4 hours after application.
Authors: Matthew J Kuehnert; Deanna Kruszon-Moran; Holly A Hill; Geraldine McQuillan; Sigrid K McAllister; Gregory Fosheim; Linda K McDougal; Jasmine Chaitram; Bette Jensen; Scott K Fridkin; George Killgore; Fred C Tenover Journal: J Infect Dis Date: 2005-12-15 Impact factor: 5.226
Authors: Sophia V Kazakova; Jeffrey C Hageman; Matthew Matava; Arjun Srinivasan; Larry Phelan; Bernard Garfinkel; Thomas Boo; Sigrid McAllister; Jim Anderson; Bette Jensen; Doug Dodson; David Lonsway; Linda K McDougal; Matthew Arduino; Victoria J Fraser; George Killgore; Fred C Tenover; Sara Cody; Daniel B Jernigan Journal: N Engl J Med Date: 2005-02-03 Impact factor: 91.245
Authors: Heiman F L Wertheim; Damian C Melles; Margreet C Vos; Willem van Leeuwen; Alex van Belkum; Henri A Verbrugh; Jan L Nouwen Journal: Lancet Infect Dis Date: 2005-12 Impact factor: 25.071