AIM: We aimed to investigate the role of platelets in the pathogenesis of cervicocephalic artery dissections by measuring the mean platelet volume (MPV) and platelet count. METHODS: Thirty-four patients with evidence of cervicocephalic artery dissection were included in the study. Cervicocephalic artery dissection patients were divided into two subgroups as vertebral artery dissections and carotid artery dissections. There were 30 control subjects with similar baseline characteristics. The platelet count and MPV were compared between groups. RESULTS: The analysis showed a significant difference between the MPV values of the cervicocephalic artery dissection group and the control group (p < 0.05). However, when we compared subgroups with controls, we found a significantly higher MPV values only in the vertebral artery dissection group. We did not find any significant difference for total platelet count between the cervicocephalic artery dissection groups and controls. CONCLUSIONS: MPV is a marker of platelet function and activation. Increased MPV may be a result of dissection. In addition, it may be a risk factor for dissection-related stroke. Our study supports the notion that platelet reactivity is important in the pathogenesis of the cervicocephalic artery dissections, especially in vertebral artery dissections.
AIM: We aimed to investigate the role of platelets in the pathogenesis of cervicocephalic artery dissections by measuring the mean platelet volume (MPV) and platelet count. METHODS: Thirty-four patients with evidence of cervicocephalic artery dissection were included in the study. Cervicocephalic artery dissection patients were divided into two subgroups as vertebral artery dissections and carotid artery dissections. There were 30 control subjects with similar baseline characteristics. The platelet count and MPV were compared between groups. RESULTS: The analysis showed a significant difference between the MPV values of the cervicocephalic artery dissection group and the control group (p < 0.05). However, when we compared subgroups with controls, we found a significantly higher MPV values only in the vertebral artery dissection group. We did not find any significant difference for total platelet count between the cervicocephalic artery dissection groups and controls. CONCLUSIONS: MPV is a marker of platelet function and activation. Increased MPV may be a result of dissection. In addition, it may be a risk factor for dissection-related stroke. Our study supports the notion that platelet reactivity is important in the pathogenesis of the cervicocephalic artery dissections, especially in vertebral artery dissections.
Authors: Domenico Paparella; Crescenzia Rotunno; Pietro Guida; Pietro Giorgio Malvindi; Giuseppe Scrascia; Micaela De Palo; Emanuela de Cillis; Alessandro S Bortone; Luigi de Luca Tupputi Schinosa Journal: Ann Thorac Surg Date: 2011-03-10 Impact factor: 4.330
Authors: S Debette; C Grond-Ginsbach; M Bodenant; M Kloss; S Engelter; T Metso; A Pezzini; T Brandt; V Caso; E Touzé; A Metso; S Canaple; S Abboud; G Giacalone; P Lyrer; E Del Zotto; M Giroud; Y Samson; J Dallongeville; T Tatlisumak; D Leys; J J Martin Journal: Neurology Date: 2011-09-07 Impact factor: 9.910
Authors: Antonio Muscari; Giovanni M Puddu; Andrea Cenni; Maria G Silvestri; Rosa Giuzio; Marzia Rosati; Nadia Santoro; Giampaolo Bianchi; Donatella Magalotti; Marco Zoli Journal: Thromb Res Date: 2008-05-09 Impact factor: 3.944