OBJECTIVES: Evaluation of the periodontal status is necessary prior to management with high-dose chemotherapy before hematopoietic stem cell therapy (HSCT). During medical therapy, pre-existing periodontal conditions may exacerbate and cause local and systemic complications. When possible, maximal oral health should be achieved prior to engraftment. In this study, we aimed to determine the alterations occurred in the periodontal status of the patients after periodontal treatment and allogenic HSCT and evaluate the effect of intensive periodontal approach on the short-term complications of HSCT. METHODS: The alterations occurred in the periodontal tissues 3-4 weeks after periodontal treatment and after HSCT periods of 3 months for 29 patients treated with full-mouth periodontal treatment completed in 24 h in addition to eradication of dental foci, and oral hygiene status were evaluated using pocket depth measurements, presence of bleeding on probing and plaque and gingival indices. The incidence and severity of acute graft-versus-host disease (GVHD) and oral mucositis (OM) were recorded. Duration of engraftment period and the episode of febrile neutropenia were also evaluated. RESULTS: There were significant improvements in periodontal status after periodontal treatment (P<0.001). There were 14 (48.3%) patients without acute GVHD and 17 (58.6%) patients with no sign of OM. The majority of OM was at grade II level. There was a negative relation that exists between the percentage of BOP (+) sites and presence of OM (r=-0.518, P<0.05). CONCLUSIONS: Together with a significant reduction in gingival inflammation and maintenance of the improvement in periodontal health, remarkable decrease in the incidence and severity of OM were observed.
OBJECTIVES: Evaluation of the periodontal status is necessary prior to management with high-dose chemotherapy before hematopoietic stem cell therapy (HSCT). During medical therapy, pre-existing periodontal conditions may exacerbate and cause local and systemic complications. When possible, maximal oral health should be achieved prior to engraftment. In this study, we aimed to determine the alterations occurred in the periodontal status of the patients after periodontal treatment and allogenic HSCT and evaluate the effect of intensive periodontal approach on the short-term complications of HSCT. METHODS: The alterations occurred in the periodontal tissues 3-4 weeks after periodontal treatment and after HSCT periods of 3 months for 29 patients treated with full-mouth periodontal treatment completed in 24 h in addition to eradication of dental foci, and oral hygiene status were evaluated using pocket depth measurements, presence of bleeding on probing and plaque and gingival indices. The incidence and severity of acute graft-versus-host disease (GVHD) and oral mucositis (OM) were recorded. Duration of engraftment period and the episode of febrile neutropenia were also evaluated. RESULTS: There were significant improvements in periodontal status after periodontal treatment (P<0.001). There were 14 (48.3%) patients without acute GVHD and 17 (58.6%) patients with no sign of OM. The majority of OM was at grade II level. There was a negative relation that exists between the percentage of BOP (+) sites and presence of OM (r=-0.518, P<0.05). CONCLUSIONS: Together with a significant reduction in gingival inflammation and maintenance of the improvement in periodontal health, remarkable decrease in the incidence and severity of OM were observed.
Authors: J E Tinoco-Araujo; E S L Orti-Raduan; D Santos; V A R Colturato; M P Souza; M A Mauad; T C M Saggioro; R S Bastos; P S da Silva Santos Journal: Clin Oral Investig Date: 2015-04-01 Impact factor: 3.573
Authors: Catherine H L Hong; Shijia Hu; Thijs Haverman; Monique Stokman; Joel J Napeñas; Jacolien Bos-den Braber; Erich Gerber; Margot Geuke; Emmanouil Vardas; Tuomas Waltimo; Siri Beier Jensen; Deborah P Saunders Journal: Support Care Cancer Date: 2017-07-22 Impact factor: 3.603
Authors: Kirsten M Williams; Yoshihiro Inamoto; Annie Im; Betty Hamilton; John Koreth; Mukta Arora; Iskra Pusic; Jacqueline W Mays; Paul A Carpenter; Leo Luznik; Pavan Reddy; Jerome Ritz; Hildegard Greinix; Sophie Paczesny; Bruce R Blazar; Joseph Pidala; Corey Cutler; Daniel Wolff; Kirk R Schultz; Steven Z Pavletic; Stephanie J Lee; Paul J Martin; Gerard Socie; Stefanie Sarantopoulos Journal: Transplant Cell Ther Date: 2021-03-02
Authors: Judith A E M Zecha; Judith E Raber-Durlacher; Alexa M G A Laheij; Anneke M Westermann; Joel B Epstein; Jan de Lange; Ludi E Smeele Journal: Support Care Cancer Date: 2019-06-20 Impact factor: 3.603