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Literature DB >> 22487298

Effects of aging on articular cartilage homeostasis.

Abstract

This review is focused on aging-related changes in cells and extracellular matrix of the articular cartilage. Major extracellular matrix changes are a reduced thickness of cartilage, proteolysis, advanced glycation and calcification. The cellular changes include reduced cell density, cellular senescence with abnormal secretory profiles, and impaired cellular defense mechanisms and anabolic responses. The extracellular and cellular changes compound each other, leading to biomechanical dysfunction and tissue destruction. The consequences of aging-related changes for joint homeostasis and risk for osteoarthritis are discussed. This article is part of a Special Issue entitled "Osteoarthritis".

Entities: Chemical Disease Gene Species

Mesh：

Year: 2012 PMID： 22487298 PMCID： PMC3372644 DOI： 10.1016/j.bone.2012.03.023

Source DB: PubMed Journal: Bone ISSN： 1873-2763 Impact factor: 4.398

127 in total

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107 in total

1. Cysteine-Mediated Redox Regulation of Cell Signaling in Chondrocytes Stimulated With Fibronectin Fragments.

Authors: Scott T Wood; David L Long; Julie A Reisz; Raghunatha R Yammani; Elizabeth A Burke; Chananat Klomsiri; Leslie B Poole; Cristina M Furdui; Richard F Loeser
Journal: Arthritis Rheumatol Date: 2016-01 Impact factor: 10.995

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Journal: Arthritis Rheumatol Date: 2015-05 Impact factor: 10.995

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Journal: Arthritis Rheumatol Date: 2017-06-02 Impact factor: 10.995

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Journal: Arthritis Rheumatol Date: 2014-11 Impact factor: 10.995

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Journal: Arthritis Rheum Date: 2013-07