BACKGROUND: The effect of immunomodulator therapy (IMT) for multiple sclerosis (MS) on bone turnover is unknown. AIM: The aim of this study was to assess bone turnover in MS patients on IMT. METHODS: MS patients (n = 29) on maintenance IMT had repeat measurement of bone mineral density (BMD) after a 4.0 ± 0.4 years; bone turnover markers (BTM) were measured at the time of repeat BMD. RESULTS: BMD was unchanged at the spine but declined at the hip. BTMs, both resorption and formation, were reduced compared to normative range that may indicate an anti-resorptive action of IMT. Significant negative correlations were noted between BTMs and changes in BMD at spine but not hip. CONCLUSION: These observations suggest that IMT may have a beneficial effect on spinal bone by an antiresorptive action. A prospective study of the effect of IMT on BMD and bone turnover is warranted.
BACKGROUND: The effect of immunomodulator therapy (IMT) for multiple sclerosis (MS) on bone turnover is unknown. AIM: The aim of this study was to assess bone turnover in MS patients on IMT. METHODS: MS patients (n = 29) on maintenance IMT had repeat measurement of bone mineral density (BMD) after a 4.0 ± 0.4 years; bone turnover markers (BTM) were measured at the time of repeat BMD. RESULTS: BMD was unchanged at the spine but declined at the hip. BTMs, both resorption and formation, were reduced compared to normative range that may indicate an anti-resorptive action of IMT. Significant negative correlations were noted between BTMs and changes in BMD at spine but not hip. CONCLUSION: These observations suggest that IMT may have a beneficial effect on spinal bone by an antiresorptive action. A prospective study of the effect of IMT on BMD and bone turnover is warranted.
Authors: A T Reder; G C Ebers; A Traboulsee; D Li; D Langdon; D S Goodin; T Bogumil; K Beckmann; A Konieczny Journal: Neurology Date: 2010-06-08 Impact factor: 9.910
Authors: A C Looker; H W Wahner; W L Dunn; M S Calvo; T B Harris; S P Heyse; C C Johnston; R L Lindsay Journal: Osteoporos Int Date: 1995 Impact factor: 4.507
Authors: Caitriona Ryan; Benvon Moran; Malachi J McKenna; Barbara F Murray; Jennifer Brady; Paul Collins; Sarah Rogers; Brian Kirby Journal: Arch Dermatol Date: 2010-08
Authors: Kavinderjit S Nanda; Elizabeth J Ryan; Barbara F Murray; Jennifer J Brady; Malachi J McKenna; Niamh Nolan; Cliona O'Farrelly; John E Hegarty Journal: Clin Gastroenterol Hepatol Date: 2009-01-24 Impact factor: 11.382