| Literature DB >> 22484497 |
Hui Zhang1, Xiaofang Zhang2, Xiaojuan Wu3, Weiwei Li4, Peng Su5, Hongxia Cheng6, Lei Xiang7, Peng Gao8, Gengyin Zhou9.
Abstract
Multidrug resistance (MDR) represents a major obstacle in the successful treatment of breast cancer. The MDR1 gene is a direct target of the Wnt/β-catenin signaling pathway, which controls tumor development. Overexpression of P-glycoprotein, encoded by the MDR1 gene, is one of the most common causes of MDR. We found that the Frizzled 1 (FZD1) protein, which is an essential component of the Wnt/β-catenin pathway, is overexpressed in the multidrug resistant breast cancer cell subline MCF-7/ADM, coincident with MDR1/P-gp. FZD1 silencing induced down-regulation of MDR1/P-gp, restored sensitivity to four chemotherapy drugs, and significantly decreased cytoplasmic and nuclear β-catenin levels. FZD1 appears to mediate multidrug resistance by regulating the Wnt/β-catenin pathway.Entities:
Mesh：
Substances：
Year: 2012 PMID： 22484497 DOI： 10.1016/j.canlet.2012.03.039
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679