Literature DB >> 22484040

A fluorescence-based analysis of aristolochic acid-derived DNA adducts.

Victor Romanov1, Victoria Sidorenko, Thomas A Rosenquist, Terry Whyard, Arthur P Grollman.   

Abstract

Aristolochic acids (AAs), major components of plant extracts from Aristolochia species, form (after metabolic activation) pro-mutagenic DNA adducts in renal tissue. The DNA adducts can be used as biomarkers for studies of AA toxicity. Identification of these adducts is a complicated and time-consuming procedure. We present here a fast, nonisotopic, fluorescence-based assay for the detection of AA-DNA adducts in multiple samples. This approach allows analysis of AA adducts in synthetic DNA with known nucleotide composition and analysis of DNA adducts formed from chemically diverse AAs in vitro. The method can be applied to compare AA-DNA adduct formation in cells and tissues.
Copyright © 2012 Elsevier Inc. All rights reserved.

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Year:  2012        PMID： 22484040      PMCID： PMC3383895          DOI： 10.1016/j.ab.2012.03.027

Source DB:  PubMed          Journal:  Anal Biochem        ISSN： 0003-2697            Impact factor:   3.365


  17 in total

1.  Aristolactam-DNA adducts are a biomarker of environmental exposure to aristolochic acid.

Authors:  Bojan Jelaković; Sandra Karanović; Ivana Vuković-Lela; Frederick Miller; Karen L Edwards; Jovan Nikolić; Karla Tomić; Neda Slade; Branko Brdar; Robert J Turesky; Želimir Stipančić; Damir Dittrich; Arthur P Grollman; Kathleen G Dickman
Journal:  Kidney Int       Date:  2011-11-09       Impact factor: 10.612

2.  Aristolochic acid (AA)-DNA adduct as marker of AA exposure and risk factor for AA nephropathy-associated cancer.

Authors:  Volker M Arlt; Véronique Alunni-Perret; Gérald Quatrehomme; Patrick Ohayon; Laetitia Albano; Hacène Gaïd; Jean-Francois Michiels; Alain Meyrier; Elisabeth Cassuto; Manfred Wiessler; Heinz H Schmeiser; Jean-Pierre Cosyns
Journal:  Int J Cancer       Date:  2004-10-10       Impact factor: 7.396

3.  Comparison of DNA adduct formation by aristolochic acids in various in vitro activation systems by 32P-post-labelling: evidence for reductive activation by peroxidases.

Authors:  H H Schmeiser; E Frei; M Wiessler; M Stiborova
Journal:  Carcinogenesis       Date:  1997-05       Impact factor: 4.944

4.  Aristolochic acid I-induced DNA damage and cell cycle arrest in renal tubular epithelial cells in vitro.

Authors:  Ying Li; Zhihong Liu; Xiaohua Guo; Jian Shu; Zhaohong Chen; Leishi Li
Journal:  Arch Toxicol       Date:  2006-04-12       Impact factor: 5.153

5.  32P-postlabeling DNA damage assays: PAGE, TLC, and HPLC.

Authors:  Shinya Shibutani; Sung Yeon Kim; Naomi Suzuki
Journal:  Methods Mol Biol       Date:  2006

6.  Quantitative determination of aristolochic acid-derived DNA adducts in rats using 32P-postlabeling/polyacrylamide gel electrophoresis analysis.

Authors:  Huan Dong; Naomi Suzuki; Maria C Torres; Radha R Bonala; Francis Johnson; Arthur P Grollman; Shinya Shibutani
Journal:  Drug Metab Dispos       Date:  2006-04-12       Impact factor: 3.922

7.  Quantification of aristolochic acid-derived DNA adducts in rat kidney and liver by using liquid chromatography-electrospray ionization mass spectrometry.

Authors:  Wan Chan; Hao Yue; Wing Tat Poon; Yan-Wo Chan; Oliver J Schmitz; Daniel W J Kwong; Ricky N S Wong; Zongwei Cai
Journal:  Mutat Res       Date:  2008-09-04       Impact factor: 2.433

8.  Simultaneous analysis of six aristolochic acids and five aristolactams in herbal plants and their preparations by high-performance liquid chromatography-diode array detection-fluorescence detection.

Authors:  Jinbin Yuan; Qian Liu; Weifeng Zhu; Li Ding; Fei Tang; Shouzhuo Yao
Journal:  J Chromatogr A       Date:  2008-01-06       Impact factor: 4.759

9.  Biotransformation enzymes in development of renal injury and urothelial cancer caused by aristolochic acid.

Authors:  M Stiborová; E Frei; H H Schmeiser
Journal:  Kidney Int       Date:  2008-06       Impact factor: 10.612

10.  Aristolochic acid and the etiology of endemic (Balkan) nephropathy.

Authors:  Arthur P Grollman; Shinya Shibutani; Masaaki Moriya; Frederick Miller; Lin Wu; Ute Moll; Naomi Suzuki; Andrea Fernandes; Thomas Rosenquist; Zvonimir Medverec; Krunoslav Jakovina; Branko Brdar; Neda Slade; Robert J Turesky; Angela K Goodenough; Robert Rieger; Mato Vukelić; Bojan Jelaković
Journal:  Proc Natl Acad Sci U S A       Date:  2007-07-09       Impact factor: 11.205
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  1 in total

1.  Defining in vivo dose-response curves for kidney DNA adduct formation of aristolochic acid I in rat, mouse and human by an in vitro and physiologically based kinetic modeling approach.

Authors:  Rozaini Abdullah; Sebastiaan Wesseling; Bert Spenkelink; Jochem Louisse; Ans Punt; Ivonne M C M Rietjens
Journal:  J Appl Toxicol       Date:  2020-07-07       Impact factor: 3.446
  1 in total

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