Literature DB >> 22483988

PIWIL4 regulates cervical cancer cell line growth and is involved in down-regulating the expression of p14ARF and p53.

Chang Su1, Zhong-Jie Ren, Fang Wang, Min Liu, Xin Li, Hua Tang.   

Abstract

Recently, PIWIL4 has been identified as a functional protein involved in tumorigenesis. Cervical cancer is the second most prevalent form of cancer worldwide. The relationship between PIWIL4 and cervical cancer is still unknown. Here, we found that PIWIL4 is up-regulated in human cervical cancer tissues in comparison to adjacent normal tissues, and it promotes cell growth and proliferation by inhibiting apoptosis through the p14ARF/p53 pathway. PIWIL4 can also promote the invasion of cervical cancer cells. These results suggest that PIWIL4 might play an oncogenic role in cervical cancer and be useful as a new therapeutic target in the future.
Copyright © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Year:  2012        PMID： 22483988     DOI： 10.1016/j.febslet.2012.03.053

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  16 in total

1.  PIWI-interacting RNAs as novel regulators of pancreatic beta cell function.

Authors:  Imène Sarah Henaoui; Cécile Jacovetti; Inês Guerra Mollet; Claudiane Guay; Jonathan Sobel; Lena Eliasson; Romano Regazzi
Journal:  Diabetologia       Date:  2017-07-16       Impact factor: 10.122

2.  Possible role of HIWI2 in modulating tight junction proteins in retinal pigment epithelial cells through Akt signaling pathway.

Authors:  Suganya Sivagurunathan; Karthikka Palanisamy; Jayamuruga Pandian Arunachalam; Subbulakshmi Chidambaram
Journal:  Mol Cell Biochem       Date:  2016-12-26       Impact factor: 3.396

Review 3.  Piwi-interacting RNAs (piRNAs) and cancer: Emerging biological concepts and potential clinical implications.

Authors:  Wenhao Weng; Hanhua Li; Ajay Goel
Journal:  Biochim Biophys Acta Rev Cancer       Date:  2018-12-30       Impact factor: 10.680

4.  CRNDE Promotes Malignant Progression of Glioma by Attenuating miR-384/PIWIL4/STAT3 Axis.

Authors:  Jian Zheng; Xiaobai Liu; Ping Wang; Yixue Xue; Jun Ma; Chengbin Qu; Yunhui Liu
Journal:  Mol Ther       Date:  2016-04-08       Impact factor: 11.454

5.  Expression and Regulation of PIWIL-Proteins and PIWI-Interacting RNAs in Rheumatoid Arthritis.

Authors:  Lenka Pleštilová; Michel Neidhart; Giancarlo Russo; Mojca Frank-Bertoncelj; Caroline Ospelt; Adrian Ciurea; Christoph Kolling; Renate E Gay; Beat A Michel; Jiří Vencovský; Steffen Gay; Astrid Jüngel
Journal:  PLoS One       Date:  2016-11-28       Impact factor: 3.240

6.  The meaning of PIWI proteins in cancer development.

Authors:  Monika Litwin; Anna Szczepańska-Buda; Aleksandra Piotrowska; Piotr Dzięgiel; Wojciech Witkiewicz
Journal:  Oncol Lett       Date:  2017-03-28       Impact factor: 2.967

Review 7.  Beyond MicroRNAs: Emerging Role of Other Non-Coding RNAs in HPV-Driven Cancers.

Authors:  Mariateresa Casarotto; Giuseppe Fanetti; Roberto Guerrieri; Elisa Palazzari; Valentina Lupato; Agostino Steffan; Jerry Polesel; Paolo Boscolo-Rizzo; Elisabetta Fratta
Journal:  Cancers (Basel)       Date:  2020-05-15       Impact factor: 6.639

Review 8.  Epigenetic roles of PIWI proteins and piRNAs in colorectal cancer.

Authors:  Fatemeh Sadoughi; Seyyed Mehdi Mirhashemi; Zatollah Asemi
Journal:  Cancer Cell Int       Date:  2021-06-30       Impact factor: 5.722

Review 9.  PIWI proteins and piRNAs in cervical cancer: a propitious dart in cancer stem cell-targeted therapy.

Authors:  Midhunaraj Kunnummal; Mary Angelin; Ani V Das
Journal:  Hum Cell       Date:  2021-08-09       Impact factor: 4.374

10.  PIWI-like protein, HIWI2 is aberrantly expressed in retinoblastoma cells and affects cell-cycle potentially through OTX2.

Authors:  Suganya Sivagurunathan; Jayamuruga Pandian Arunachalam; Subbulakshmi Chidambaram
Journal:  Cell Mol Biol Lett       Date:  2017-08-29       Impact factor: 5.787
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