Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The role of the catechol-O-methyltransferase (COMT) gene in personality and related psychopathological disorders.

Literature DB >> 22483293

The role of the catechol-O-methyltransferase (COMT) gene in personality and related psychopathological disorders.

Christian Montag¹, Magdalena Jurkiewicz, Martin Reuter.

Abstract

This review provides a short overview of the most significant biologically oriented theories of human personality. Personality concepts of Eysenck, Gray and McNaughton, Cloninger and Panksepp will be introduced and the focal evidence for the heritability of personality will be summarized. In this context, a synopsis of a large number of COMT genetic association studies (with a focus on the COMT Val158Met polymorphism) in the framework of the introduced biologically oriented personality theories will be given. In line with the theory of a continuum model between healthy anxious behavior and related psychopathological behavior, the role of the COMT gene in anxiety disorders will be discussed. A final outlook considers new research strategies such as genetic imaging and epigenetics for a better understanding of human personality.

Entities: Chemical Disease Gene Mutation Species

Mesh：

Substances：

Year: 2012 PMID： 22483293 PMCID： PMC4345409 DOI： 10.2174/187152712800672382

Source DB: PubMed Journal: CNS Neurol Disord Drug Targets ISSN： 1871-5273 Impact factor: 4.388

96 in total

1. Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers.

Authors: E G Jönsson; M M Nöthen; F Grünhage; L Farde; Y Nakashima; P Propping; G C Sedvall
Journal: Mol Psychiatry Date: 1999-05 Impact factor: 15.992

2. The electroencephalogram (EEG) as a research tool in human behavior genetics: psychological examinations in healthy males with various inherited EEG variants. III. Interpretation of the results.

Authors: F Vogel; E Schalt
Journal: Hum Genet Date: 1979-02-28 Impact factor: 4.132

3. The COMT Val158Met polymorphism is associated with novelty seeking in Czech methamphetamine abusers: preliminary results.

Authors: Ladislav Hosák; Jan Libiger; Jiri Cizek; Martin Beránek; Eva Cermáková
Journal: Neuro Endocrinol Lett Date: 2006-12 Impact factor: 0.765

4. Schizotypal dimensions: an intermediate phenotype associated with the COMT high activity allele.

Authors: Franck Schürhoff; Andrei Szöke; Fabien Chevalier; Isabelle Roy; Alexandre Méary; Frank Bellivier; Bruno Giros; Marion Leboyer
Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2007-01-05 Impact factor: 3.568

5. The nicotinic acetylcholine receptor gene CHRNA4 is associated with negative emotionality.

Authors: Sebastian Markett; Christian Montag; Martin Reuter
Journal: Emotion Date: 2011-04

6. Association study of catechol-O-methyltransferase Val158Met polymorphism with personality traits in Japanese healthy volunteers.

Authors: Genki Ishii; Akihito Suzuki; Shingo Oshino; Hiroaki Shiraishi; Yoshihiko Matsumoto; Koichi Otani; Kaoru Goto
Journal: Eur Psychiatry Date: 2007-08-30 Impact factor: 5.361

Review 7. Treatment of cognitive deficits associated with schizophrenia: potential role of catechol-O-methyltransferase inhibitors.

Authors: José A Apud; Daniel R Weinberger
Journal: CNS Drugs Date: 2007 Impact factor: 5.749

8. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene.

Authors: Avshalom Caspi; Karen Sugden; Terrie E Moffitt; Alan Taylor; Ian W Craig; HonaLee Harrington; Joseph McClay; Jonathan Mill; Judy Martin; Antony Braithwaite; Richie Poulton
Journal: Science Date: 2003-07-18 Impact factor: 47.728

9. Neurophysiological and genetic distinctions between pure and comorbid anxiety disorders.

Authors: Mary-Anne Enoch; Kenneth V White; Juwaria Waheed; David Goldman
Journal: Depress Anxiety Date: 2008 Impact factor: 6.505

10. Sensorimotor gating depends on polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase, but not on neuregulin-1 Arg38Gln genotype: a replication study.

Authors: Boris B Quednow; Anne Schmechtig; Ulrich Ettinger; Nadine Petrovsky; David A Collier; Franz X Vollenweider; Michael Wagner; Veena Kumari
Journal: Biol Psychiatry Date: 2009-06-28 Impact factor: 13.382

17 in total

The role of the catechol-O-methyltransferase (COMT) gene in personality and related psychopathological disorders.

1. Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers.

2. The electroencephalogram (EEG) as a research tool in human behavior genetics: psychological examinations in healthy males with various inherited EEG variants. III. Interpretation of the results.

3. The COMT Val158Met polymorphism is associated with novelty seeking in Czech methamphetamine abusers: preliminary results.

4. Schizotypal dimensions: an intermediate phenotype associated with the COMT high activity allele.

5. The nicotinic acetylcholine receptor gene CHRNA4 is associated with negative emotionality.

6. Association study of catechol-O-methyltransferase Val158Met polymorphism with personality traits in Japanese healthy volunteers.

Review 7. Treatment of cognitive deficits associated with schizophrenia: potential role of catechol-O-methyltransferase inhibitors.

8. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene.

9. Neurophysiological and genetic distinctions between pure and comorbid anxiety disorders.

10. Sensorimotor gating depends on polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase, but not on neuregulin-1 Arg38Gln genotype: a replication study.

Review 1. Novelty Seeking and Drug Addiction in Humans and Animals: From Behavior to Molecules.

2. Overlapping dopaminergic pathway genetic susceptibility to heroin and cocaine addictions in African Americans.

3. Systems pharmacogenomics - gene, disease, drug and placebo interactions: a case study in COMT.

4. A new measure for the revised reinforcement sensitivity theory: psychometric criteria and genetic validation.

Review 5. An Overview of the Association between Schizotypy and Dopamine.

6. Playing nice: a multi-methodological study on the effects of social conformity on memory.

7. Common genetic variation of the APOE gene and personality.

8. Preliminary investigation of the influence of dopamine regulating genes on social working memory.

9. The influence of COMT Val¹⁵⁸Met genotype on the character dimension cooperativeness in healthy females.

10. Influence of COMT genotype and affective distractors on the processing of self-generated thought.