BACKGROUND: The vegetal biomembrane has been used to treat cutaneous ulcers. OBJECTIVES: To assess the role of the vegetal biomembrane on the chronic venous ulcers treatment compared to treatment with collagenase cream. METHODS:Fourteen patients were selected to be treated with vegetal biomembrane and 7 with Fibrase(®) (CONTROL), followed clinically and photographically by the Wound Healing Index by ImageJ during 120 days and biopsied on the 1(st) and 30(th) days for histological examination. RESULTS: The vegetal biomembrane was better in promoting healing of the ulcers, especially on the inflammatory phase, confirmed by abundant exudation and wound debridement than the CONTROL group, on the 30th day. There was a greater tendency to angiogenesis followed by re-epithelialization with highest wound healing index on the 90(th) and 120(th) days. CONCLUSION: A combined analysis of clinical and histopathological findings suggests that the vegetal biomembrane acted as a factor inducing wound healing, especially on the inflammatory phase, confirmed by abundant exudation of the lesions promoting the transformation of the microenvironment of the chronic venous ulcers, and also stimulating angiogenesis and subsequent re-epithelialization.
RCT Entities:
BACKGROUND: The vegetal biomembrane has been used to treat cutaneous ulcers. OBJECTIVES: To assess the role of the vegetal biomembrane on the chronic venous ulcers treatment compared to treatment with collagenase cream. METHODS: Fourteen patients were selected to be treated with vegetal biomembrane and 7 with Fibrase(®) (CONTROL), followed clinically and photographically by the Wound Healing Index by ImageJ during 120 days and biopsied on the 1(st) and 30(th) days for histological examination. RESULTS: The vegetal biomembrane was better in promoting healing of the ulcers, especially on the inflammatory phase, confirmed by abundant exudation and wound debridement than the CONTROL group, on the 30th day. There was a greater tendency to angiogenesis followed by re-epithelialization with highest wound healing index on the 90(th) and 120(th) days. CONCLUSION: A combined analysis of clinical and histopathological findings suggests that the vegetal biomembrane acted as a factor inducing wound healing, especially on the inflammatory phase, confirmed by abundant exudation of the lesions promoting the transformation of the microenvironment of the chronic venous ulcers, and also stimulating angiogenesis and subsequent re-epithelialization.
Authors: Anderson L Freitas; Carla A Santos; Carlos As Souza; Marco Ap Nunes; Ângelo R Antoniolli; Wellington B da Silva; Francilene A da Silva Journal: Int Wound J Date: 2017-05-09 Impact factor: 3.315
Authors: Luciane Madureira Almeida; Juliana Ferreira Floriano; Thuanne Pires Ribeiro; Lais Nogueira Magno; Lígia Souza Lima Silveira da Mota; Nei Peixoto; Fátima Mrué; Paulo Melo-Reis; Ruy de Souza Lino Junior; Carlos Frederico de Oliveira Graeff; Pablo José Gonçalves Journal: J Mater Sci Mater Med Date: 2014-06-29 Impact factor: 3.896
Authors: Virginia Januário; Dione Augusto de Ávila; Maria Alice Penetra; Ana Luisa Bittencourt Sampaio; Maria Isabel Noronha Neta; Flavia de Freire Cassia; Sueli Carneiro Journal: An Bras Dermatol Date: 2016 Jan-Feb Impact factor: 1.896
Authors: Gill Norman; Maggie J Westby; Amber D Rithalia; Nikki Stubbs; Marta O Soares; Jo C Dumville Journal: Cochrane Database Syst Rev Date: 2018-06-15