| Literature DB >> 22481606 |
Philippe R Mutwa1, Quirine Fillekes, Marie Malgaz, Diane Tuyishimire, Rianne van de Kraats, Kimberly R Boer, David M Burger, Ron H N van Schaik, Narcisse Muganga, Sibyl P M Geelen.
Abstract
This study evaluated mid-dosing interval efavirenz plasma concentrations and the influence of CYP2B6 polymorphisms in relation to efficacy, tolerability, and adherence in 97 Rwandan HIV-infected children (3-16 years). Plasma drug concentrations and CYP2B6 polymorphisms were determined. Ten children were excluded for nonadherence. Large intersubject variability in efavirenz plasma concentrations was found. Of the 87 remaining, efavirenz concentrations were therapeutic, supratherapeutic, and subtherapeutic in 67%, 20%, and 14%, respectively. No associations were found between efavirenz concentrations and central nervous system disturbances or virologic failure. Minor allele frequencies were 0.32 (516G>T), 0.33 (785A>G), and 0.09 (983T>C). Polymorphisms in CYP2B6 were strongly associated with high efavirenz levels.Entities:
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Year: 2012 PMID： 22481606 DOI： 10.1097/QAI.0b013e3182569f57
Source DB: PubMed Journal: J Acquir Immune Defic Syndr ISSN： 1525-4135 Impact factor: 3.731