| Literature DB >> 22480775 |
Patrice Nordmann1, Laurent Dortet, Laurent Poirel.
Abstract
The current worldwide emergence of resistance to the powerful antibiotic carbapenem in Enterobacteriaceae constitutes an important growing public health threat. Sporadic outbreaks or endemic situations with enterobacterial isolates not susceptible to carbapenems are now reported not only in hospital settings but also in the community. Acquired class A (KPC), class B (IMP, VIM, NDM), or class D (OXA-48, OXA-181) carbapenemases, are the most important determinants sustaining resistance to carbapenems. The corresponding genes are mostly plasmid-located and associated with various mobile genetic structures (insertion sequences, integrons, transposons), further enhancing their spread. This review summarizes the current knowledge on carbapenem resistance in Enterobacteriaceae, including activity, distribution, clinical impact, and possible novel antibiotic pathways.Entities:
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Year: 2012 PMID： 22480775 DOI： 10.1016/j.molmed.2012.03.003
Source DB: PubMed Journal: Trends Mol Med ISSN： 1471-4914 Impact factor: 11.951