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Literature DB >> 22476981

NALCN: a regulator of pacemaker activity.

Abstract

Pacemaker cells play a fundamental role in generating or regulating many essential biological rhythms. Spontaneous pacemaker activity is dependent on the function of an array of ion channels expressed in these cells. Recent characterization of a Na(+) leak channel (NALCN) has linked to its role in conducting the background Na(+) current that depolarizes resting membrane properties of pacemaker neurons. NALCN, along with Unc79 and Unc80, forms a protein complex that is involved in regulating intrinsic membrane and synaptic activities. In this review, we will discuss the current understanding of NALCN channel physiology and its role in regulating cell excitability and pacemaker activity.

Entities: Gene

Mesh：

Substances：
Sodium Channels

Year: 2012 PMID： 22476981 DOI： 10.1007/s12035-012-8260-2

Source DB: PubMed Journal: Mol Neurobiol ISSN： 0893-7648 Impact factor: 5.590

77 in total

1. Functional role of L-type Cav1.3 Ca2+ channels in cardiac pacemaker activity.

Authors: Matteo E Mangoni; Brigitte Couette; Emmanuel Bourinet; Josef Platzer; Daniel Reimer; Jörg Striessnig; Joël Nargeot
Journal: Proc Natl Acad Sci U S A Date: 2003-04-16 Impact factor: 11.205

2. Localization of f-channels to caveolae mediates specific beta2-adrenergic receptor modulation of rate in sinoatrial myocytes.

Authors: Andrea Barbuti; Benedetta Terragni; Chiara Brioschi; Dario DiFrancesco
Journal: J Mol Cell Cardiol Date: 2006-10-30 Impact factor: 5.000

7. The effect of neurospecific knockdown of candidate genes for locomotor behavior and sound production in Drosophila melanogaster.

Authors: Sergey A Fedotov; Julia V Bragina; Natalia G Besedina; Larisa V Danilenkova; Elena A Kamysheva; Anna A Panova; Nikolai G Kamyshev
Journal: Fly (Austin) Date: 2014 Impact factor: 2.160

7 in total

NALCN: a regulator of pacemaker activity.

1. Functional role of L-type Cav1.3 Ca2+ channels in cardiac pacemaker activity.

2. Localization of f-channels to caveolae mediates specific beta2-adrenergic receptor modulation of rate in sinoatrial myocytes.

Review 3. The neuronal background K2P channels: focus on TREK1.

Review 4. The NALCN ion channel is a new actor in pancreatic β-cell physiology.

5. Properties of the hyperpolarizing-activated current (if) in cells isolated from the rabbit sino-atrial node.

6. Effects of barium, lanthanum and gadolinium on endogenous chloride and potassium currents in Xenopus oocytes.

Review 7. Neuronal mechanisms of respiratory rhythm generation: an approach using in vitro preparation.

Review 8. Sodium leak channels in neuronal excitability and rhythmic behaviors.

9. A genetic study of the anesthetic response: mutants of Drosophila melanogaster altered in sensitivity to halothane.

10. Characteristics of a human N-type calcium channel expressed in HEK293 cells.

1. A balance of outward and linear inward ionic currents is required for generation of slow-wave oscillations.

2. A uniquely adaptable pore is consistent with NALCN being an ion sensor.

3. The role of linear and voltage-dependent ionic currents in the generation of slow wave oscillations.

Review 4. The sodium leak channel, NALCN, in health and disease.

5. The Values of Coronary Circulating miRNAs in Patients with Atrial Fibrillation.

6. Novel human genome variants associated with alcohol use disorders identified in a Lithuanian cohort.

7. The effect of neurospecific knockdown of candidate genes for locomotor behavior and sound production in Drosophila melanogaster.