Literature DB >> 22476955

Acute spinal cord injury induces genetic damage in multiple organs of rats.

Carla C Medalha1, Fernanda S Polesel, Victor Hugo Pereira da Silva, Renato Almeida Martins, Renan Pozzi, Daniel A Ribeiro.   

Abstract

Spinal cord injury (SCI) is a devastating condition with important functional and psychological consequences. However, the underlying mechanisms by which these alterations occur are still not fully understood. The aim of this study was to analyze genomic instability in multiple organs in the acute phase of SCI by means of single cell gel (comet) assay. Rats were randomly distributed into two groups (n = 5): a SHAM and a SCI group killed 24 h after cord transection surgery. The results pointed out genetic damage in blood cells as depicted by the tail moment results. DNA breakage was also detected in liver and kidney cells after SCI. Taken together, our results suggest that SCI induces genomic damage in multiple organs of Wistar rats.

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Year:  2012        PMID： 22476955     DOI： 10.1007/s10571-012-9825-3

Source DB:  PubMed          Journal:  Cell Mol Neurobiol        ISSN： 0272-4340            Impact factor:   5.046


  20 in total

1.  Systemic microcirculation after complete high and low thoracic spinal cord section in rats.

Authors:  Gabriel Guízar-Sahagún; Lizbeth Velasco-Hernández; Angelina Martínez-Cruz; Gilberto Castañeda-Hernández; Guadalupe Bravo; Guillermo Rojas; Enrique Hong
Journal:  J Neurotrauma       Date:  2004-11       Impact factor: 5.269

2.  Genomic damage in the progression of chronic kidney disease in rats.

Authors:  Camila Hirotsu; Sergio Tufik; Daniel A Ribeiro; Tathiana A Alvarenga; Monica L Andersen
Journal:  Brain Behav Immun       Date:  2010-10-23       Impact factor: 7.217

Review 3.  Pathophysiological mechanisms involved in systemic and metabolic alterations secondary to spinal cord injury.

Authors:  G Guízar-Sahagún; G Castañeda-Hernández; P García-López; R Franco-Bourland; I Grijalva; I Madrazo
Journal:  Proc West Pharmacol Soc       Date:  1998

4.  Differential response related to genotoxicity in multiple organs of cirrhotic rats.

Authors:  Marcia R Nagaoka; Luciana Le Sueur-Maluf; Odair Aguiar; Glaucia M Castro; Regina C Spadari-Bratfisch; Daniel A Ribeiro
Journal:  Hepatol Int       Date:  2011-01-06       Impact factor: 6.047

5.  Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing.

Authors:  R R Tice; E Agurell; D Anderson; B Burlinson; A Hartmann; H Kobayashi; Y Miyamae; E Rojas; J C Ryu; Y F Sasaki
Journal:  Environ Mol Mutagen       Date:  2000       Impact factor: 3.216

6.  Genomic instability in blood cells from murine model of mucopolysaccharidosis type I.

Authors:  Juliana Noguti; Vanessa Gonçalves Pereira; Ana Maria Martins; Vânia D'Almeida; Daniel Araki Ribeiro
Journal:  J Mol Histol       Date:  2011-10-01       Impact factor: 2.611

Review 7.  Immune system-neuroendocrine dysregulation in spinal cord injury.

Authors:  J M Cruse; J C Keith; M L Bryant; R E Lewis
Journal:  Immunol Res       Date:  1996       Impact factor: 2.829

8.  Vitamin C prevents DNA damage induced by renovascular hypertension in multiple organs of Wistar rats.

Authors:  Erika Emy Nishi; Ruy Ribeiro Campos; Cassia Toledo Bergamaschi; Vitor Rossi de Almeida; Daniel Araki Ribeiro
Journal:  Hum Exp Toxicol       Date:  2010-01-06       Impact factor: 2.903

9.  Comparison of population pharmacokinetic models for gentamicin in spinal cord-injured and able-bodied patients.

Authors:  T M Gilman; S R Brunnemann; J L Segal
Journal:  Antimicrob Agents Chemother       Date:  1993-01       Impact factor: 5.191

10.  Genetic correction and analysis of induced pluripotent stem cells from a patient with gyrate atrophy.

Authors:  Sara E Howden; Athurva Gore; Zhe Li; Ho-Lim Fung; Benjamin S Nisler; Jeff Nie; Goukai Chen; Brian E McIntosh; Daniel R Gulbranson; Nicole R Diol; Seth M Taapken; David T Vereide; Karen Dyer Montgomery; Kun Zhang; David M Gamm; James A Thomson
Journal:  Proc Natl Acad Sci U S A       Date:  2011-04-04       Impact factor: 11.205
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  2 in total

Review 1.  Oxidative stress, DNA damage, and the telomeric complex as therapeutic targets in acute neurodegeneration.

Authors:  Joshua A Smith; Sookyoung Park; James S Krause; Naren L Banik
Journal:  Neurochem Int       Date:  2013-02-17       Impact factor: 3.921

2.  Serial plasma DNA levels as predictors of outcome in patients with acute traumatic cervical spinal cord injury.

Authors:  Hung-Chen Wang; Yu-Tsai Lin; Shih-Yuan Hsu; Nai-Wen Tsai; Yun-Ru Lai; Ben Yu-Jih Su; Chia-Te Kung; Cheng-Hsien Lu
Journal:  J Transl Med       Date:  2019-10-01       Impact factor: 5.531
  2 in total

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