Literature DB >> 22474954

A double-blind, randomized, clinical trial on the antileishmanial activity of a Morinda citrifolia (Noni) stem extract and its major constituents.

Fouzia A Sattar1, Fayaz Ahmed, Nadeem Ahmed, Samina A Sattar, Muhammad A K Malghani, Muhammad I Choudhary.   

Abstract

A controlled study was conducted to determine the efficiency of a topical ointment prepared from the stem extract of Morinda citrifolia against cutaneous leishmaniasis. Similarly, the in vitro antileishmanial activity of morindicone and morinthone isolated from the extract were investigated against Leishmania major. These compounds displayed good activity. Out of 40 patients, 50% showed an excellent response and 30% exhibited good improvement.

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Year:  2012        PMID： 22474954

Source DB:  PubMed          Journal:  Nat Prod Commun        ISSN： 1555-9475            Impact factor:   0.986


  8 in total

Review 1.  Interventions for Old World cutaneous leishmaniasis.

Authors:  Julio Heras-Mosteiro; Begoña Monge-Maillo; Mariona Pinart; Patricia Lopez Pereira; Ludovic Reveiz; Emely Garcia-Carrasco; Pedro Campuzano Cuadrado; Ana Royuela; Irene Mendez Roman; Rogelio López-Vélez
Journal:  Cochrane Database Syst Rev       Date:  2017-11-17

Review 2.  Plant-derived compounds in treatment of leishmaniasis.

Authors:  A Oryan
Journal:  Iran J Vet Res       Date:  2015       Impact factor: 1.376

Review 3.  Interventions for Old World cutaneous leishmaniasis.

Authors:  Julio Heras-Mosteiro; Begoña Monge-Maillo; Mariona Pinart; Patricia Lopez Pereira; Ludovic Reveiz; Emely Garcia-Carrasco; Pedro Campuzano Cuadrado; Ana Royuela; Irene Mendez Roman; Rogelio López-Vélez
Journal:  Cochrane Database Syst Rev       Date:  2017-12-01

4.  In vivo antimicrobial efficacy of 6% Morinda citrifolia, Azadirachta indica, and 3% sodium hypochlorite as root canal irrigants.

Authors:  Rajesh Podar; Gaurav P Kulkarni; Shifali S Dadu; Shraddha Singh; Shishir H Singh
Journal:  Eur J Dent       Date:  2015 Oct-Dec

Review 5.  Morinda citrifolia Linn. (Noni) and Its Potential in Obesity-Related Metabolic Dysfunction.

Authors:  Aline Carla Inada; Priscila Silva Figueiredo; Rosângela Aparecida Dos Santos-Eichler; Karine de Cássia Freitas; Priscila Aiko Hiane; Alinne Pereira de Castro; Rita de Cássia Avellaneda Guimarães
Journal:  Nutrients       Date:  2017-05-25       Impact factor: 5.717

6.  Docking studies of Vitamin C, Vitamin E, Damnacanthal and Scopoletin with human lens gamma D-crystalline.

Authors:  Satyanarayana Rentala; Sudhakar Konada; Ramakrishna Chintala; Lakshmi Narasu Mangamoori; Suryanarayana Murthy Upadhyayula; Sarva Mangala Dhurjeti
Journal:  Bioinformation       Date:  2013-08-07

7.  Ultrastructural Changes and Death of Leishmania infantum Promastigotes Induced by Morinda citrifolia Linn. Fruit (Noni) Juice Treatment.

Authors:  Fernando Almeida-Souza; Noemi Nosomi Taniwaki; Ana Cláudia Fernandes Amaral; Celeste da Silva Freitas de Souza; Kátia da Silva Calabrese; Ana Lúcia Abreu-Silva
Journal:  Evid Based Complement Alternat Med       Date:  2016-05-22       Impact factor: 2.629

8.  Morinda citrifolia Linn. Reduces Parasite Load and Modulates Cytokines and Extracellular Matrix Proteins in C57BL/6 Mice Infected with Leishmania (Leishmania) amazonensis.

Authors:  Fernando Almeida-Souza; Flávia de Oliveira Cardoso; Bruno Vinicius da Conceição Souza; Tânia Zaverucha do Valle; Joicy Cortez de Sá; Iara Dos Santos da Silva Oliveira; Celeste da Silva Freitas de Souza; Carla Junqueira Moragas Tellis; Maria do Socorro Dos Santos Chagas; Maria Dutra Behrens; Ana Lúcia Abreu-Silva; Kátia da Silva Calabrese
Journal:  PLoS Negl Trop Dis       Date:  2016-08-31
  8 in total

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