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Literature DB >> 22474005

Insight into the rescue of oxidized soluble guanylate cyclase by the activator cinaciguat.

Abstract

Nitric oxide (NO) signaling mediates many important physiological processes through the receptor soluble guanylate cyclase (sGC). Under disease conditions sGC heme can be oxidized resulting in NO insensitivity. Here, we show that the therapeutic compound cinaciguat (Cin) rescues dysfunctional sGC by direct displacement of the oxidized heme.

Entities: Chemical Disease Gene Mutation Species

Mesh：

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Year: 2012 PMID： 22474005 PMCID： PMC3477619 DOI： 10.1002/cbic.201100809

Source DB: PubMed Journal: Chembiochem ISSN： 1439-4227 Impact factor: 3.164

43 in total

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9. NO- and haem-independent activation of soluble guanylyl cyclase: molecular basis and cardiovascular implications of a new pharmacological principle.

Authors: Johannes-Peter Stasch; Peter Schmidt; Cristina Alonso-Alija; Heiner Apeler; Klaus Dembowsky; Michael Haerter; Markus Heil; Torsten Minuth; Elisabeth Perzborn; Ulrich Pleiss; Matthias Schramm; Werner Schroeder; Henning Schröder; Elke Stahl; Wolfram Steinke; Frank Wunder
Journal: Br J Pharmacol Date: 2002-07 Impact factor: 8.739

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10 in total

1. GAPDH delivers heme to soluble guanylyl cyclase.

Authors: Yue Dai; Elizabeth A Sweeny; Simon Schlanger; Arnab Ghosh; Dennis J Stuehr
Journal: J Biol Chem Date: 2020-04-30 Impact factor: 5.157

2. Smooth muscle cell CYB5R3 preserves cardiac and vascular function under chronic hypoxic stress.

Authors: Brittany G Durgin; Katherine C Wood; Scott A Hahn; Brenda McMahon; Jeffrey J Baust; Adam C Straub
Journal: J Mol Cell Cardiol Date: 2021-09-15 Impact factor: 5.000

3. Nitric Oxide-Independent Soluble Guanylate Cyclase Activation Improves Vascular Function and Cardiac Remodeling in Sickle Cell Disease.

Authors: Karin P Potoka; Katherine C Wood; Jeffrey J Baust; Marta Bueno; Scott A Hahn; Rebecca R Vanderpool; Tim Bachman; Grace M Mallampalli; David O Osei-Hwedieh; Valerie Schrott; Bin Sun; Grant C Bullock; Eva-Maria Becker-Pelster; Matthias Wittwer; Jan Stampfuss; Ilka Mathar; Johannes-Peter Stasch; Hubert Truebel; Peter Sandner; Ana L Mora; Adam C Straub; Mark T Gladwin
Journal: Am J Respir Cell Mol Biol Date: 2018-05 Impact factor: 6.914

4. Direct sGC activation bypasses NO scavenging reactions of intravascular free oxy-hemoglobin and limits vasoconstriction.

Authors: Nicolaas J H Raat; D Marcela Tabima; Patricia A C Specht; Jesús Tejero; Hunter C Champion; Daniel B Kim-Shapiro; Jeff Baust; Egbert G Mik; Mariana Hildesheim; Johannes-Peter Stasch; Eva-Maria Becker; Hubert Truebel; Mark T Gladwin
Journal: Antioxid Redox Signal Date: 2013-07-09 Impact factor: 8.401

5. Activation of haem-oxidized soluble guanylyl cyclase with BAY 60-2770 in human platelets lead to overstimulation of the cyclic GMP signaling pathway.

Authors: Camila B Mendes-Silverio; Luiz O S Leiria; Rafael P Morganti; Gabriel F Anhê; Sisi Marcondes; Fabíola Z Mónica; Gilberto De Nucci; Edson Antunes
Journal: PLoS One Date: 2012-11-08 Impact factor: 3.240

10. Multi-Compartment, Early Disruption of cGMP and cAMP Signalling in Cardiac Myocytes from the mdx Model of Duchenne Muscular Dystrophy.

Authors: Marcella Brescia; Ying-Chi Chao; Andreas Koschinski; Jakub Tomek; Manuela Zaccolo
Journal: Int J Mol Sci Date: 2020-09-25 Impact factor: 5.923