BACKGROUND: Little is known about the interrelationships among brachial flow-mediated vasodilatation (bFMD), brachial-ankle pulse wave velocity (baPWV) and brachial intima-media thickness (bIMT) in patients with and without coronary artery disease (CAD). METHODS AND RESULTS: Two-hundred consecutive patients with stable angina pectoris (SAP) were enrolled as the CAD group and 50 age-, sex- and body mass index-matched patients without CAD were selected as the non-CAD group. bFMD, diastolic blood pressure (DBP) and high-density lipoprotein cholesterol (HDL-C) in the CAD group were significantly lower. The CAD group showed significantly higher levels of hemoglobin A(1c)(HbA(1c)) and low-density lipoprotein cholesterol (LDL-C), but not baPWV. CAD was independently associated with bFMD, DBP, HbA(1c) and HDL-C. bFMD and HDL-C significantly decreased and LDL-C increased as the number of diseased vessels with significant stenosis increased. The number of diseased vessels was independently associated with bFMD and HDL-C. In addition, bFMD, bIMT, the time constant of the shear rate and the time constant of the flow rate as assessed by a new program, Trend Plus(®), were associated with the presence of CAD. Among these parameters, the presence of CAD was independently associated with bIMT as well as bFMD. CONCLUSIONS: bFMD was a better predictor of the severity of CAD than either baPWV or coronary risk factors in patients with SAP. In addition, bIMT may be a critical predictor of CAD.
BACKGROUND: Little is known about the interrelationships among brachial flow-mediated vasodilatation (bFMD), brachial-ankle pulse wave velocity (baPWV) and brachial intima-media thickness (bIMT) in patients with and without coronary artery disease (CAD). METHODS AND RESULTS: Two-hundred consecutive patients with stable angina pectoris (SAP) were enrolled as the CAD group and 50 age-, sex- and body mass index-matched patients without CAD were selected as the non-CAD group. bFMD, diastolic blood pressure (DBP) and high-density lipoprotein cholesterol (HDL-C) in the CAD group were significantly lower. The CAD group showed significantly higher levels of hemoglobin A(1c)(HbA(1c)) and low-density lipoprotein cholesterol (LDL-C), but not baPWV. CAD was independently associated with bFMD, DBP, HbA(1c) and HDL-C. bFMD and HDL-C significantly decreased and LDL-C increased as the number of diseased vessels with significant stenosis increased. The number of diseased vessels was independently associated with bFMD and HDL-C. In addition, bFMD, bIMT, the time constant of the shear rate and the time constant of the flow rate as assessed by a new program, Trend Plus(®), were associated with the presence of CAD. Among these parameters, the presence of CAD was independently associated with bIMT as well as bFMD. CONCLUSIONS: bFMD was a better predictor of the severity of CAD than either baPWV or coronary risk factors in patients with SAP. In addition, bIMT may be a critical predictor of CAD.
Authors: Darren T Beck; Jeffrey S Martin; Darren P Casey; Joseph C Avery; Paloma D Sardina; Randy W Braith Journal: Clin Exp Pharmacol Physiol Date: 2014-09 Impact factor: 2.557
Authors: Juan Francisco Sanchez Muñoz-Tsorrero; Marcos Tardio-Fernandez; Jose M Valverde-Valverde; Francisco Duque-Carrillo; Jose M Vega-Fernandez; Pedro Joya-Vazquez; Jorge Vega-Fernandez Journal: J Clin Hypertens (Greenwich) Date: 2014-04-11 Impact factor: 3.738
Authors: Ricardo Gamboa; María José Jaramillo-Estrella; María Del Rocio Martínez-Alvarado; Maria Elena Soto; Yazmin Estela Torres-Paz; David de Gonzalo-Calvo; Leonardo Del Valle-Mondragón; Rebeca López-Marure; Vicenta C Llorente-Cortés; Claudia Huesca-Gómez Journal: Arq Bras Cardiol Date: 2021-01 Impact factor: 2.000
Authors: Franz Hafner; Andrea Kieninger; Andreas Meinitzer; Thomas Gary; Harald Froehlich; Elke Haas; Gerald Hackl; Philipp Eller; Marianne Brodmann; Gerald Seinost Journal: PLoS One Date: 2014-04-16 Impact factor: 3.240