BACKGROUND: Fast transport status, acquired with time on peritoneal dialysis (PD), is a pathology induced by peritoneal exposure to bioincompatible solutions. Fast transport has important clinical consequences and should be prevented. OBJECTIVE: We analyzed the repercussions of initial peritoneal transport characteristics on the prognosis for peritoneal membrane function, and also whether the influence of peritonitis and high exposure to glucose are different according to the initial peritoneal transport characteristics or the moment when such events occur. METHODS: The study included 275 peritoneal dialysis patients with at least 2 peritoneal function studies (at baseline and 1 year). Peritoneal kinetic studies were performed at baseline and annually. Those studies consist of a 4-hour dwell with glucose (1.5% during 1981 - 1990, and 2.27% during 1991 - 2002) to calculate the peritoneal mass transfer coefficients of urea and creatinine (milliliters per minute) using a previously described mathematical model. RESULTS: Membrane prognosis and technique survival were independent of baseline transport characteristics. Fast transport and ultrafiltration (UF) failure are reversible conditions, provided that peritonitis and high glucose exposure are avoided during the early dialysis period. The first year on PD is a main determining factor for the membrane's future, and the mass transfer coefficient of creatinine at year 1 is the best functional predictor of future PD history. After 5 years on dialysis, permeability frequently increases, and UF decreases. Icodextrin is associated with peritoneal protection. CONCLUSIONS: Peritoneal membrane prognosis is independent of baseline transport characteristics. Intrinsic fast transport and low UF are reversible conditions when peritonitis and high glucose exposure are avoided during the early dialysis period. Icodextrin helps in glucose avoidance and is associated with peritoneal protection.
BACKGROUND: Fast transport status, acquired with time on peritoneal dialysis (PD), is a pathology induced by peritoneal exposure to bioincompatible solutions. Fast transport has important clinical consequences and should be prevented. OBJECTIVE: We analyzed the repercussions of initial peritoneal transport characteristics on the prognosis for peritoneal membrane function, and also whether the influence of peritonitis and high exposure to glucose are different according to the initial peritoneal transport characteristics or the moment when such events occur. METHODS: The study included 275 peritoneal dialysis patients with at least 2 peritoneal function studies (at baseline and 1 year). Peritoneal kinetic studies were performed at baseline and annually. Those studies consist of a 4-hour dwell with glucose (1.5% during 1981 - 1990, and 2.27% during 1991 - 2002) to calculate the peritoneal mass transfer coefficients of urea and creatinine (milliliters per minute) using a previously described mathematical model. RESULTS: Membrane prognosis and technique survival were independent of baseline transport characteristics. Fast transport and ultrafiltration (UF) failure are reversible conditions, provided that peritonitis and high glucose exposure are avoided during the early dialysis period. The first year on PD is a main determining factor for the membrane's future, and the mass transfer coefficient of creatinine at year 1 is the best functional predictor of future PD history. After 5 years on dialysis, permeability frequently increases, and UF decreases. Icodextrin is associated with peritoneal protection. CONCLUSIONS: Peritoneal membrane prognosis is independent of baseline transport characteristics. Intrinsic fast transport and low UF are reversible conditions when peritonitis and high glucose exposure are avoided during the early dialysis period. Icodextrin helps in glucose avoidance and is associated with peritoneal protection.
Authors: M Nakayama; Y Kawaguchi; K Yamada; T Hasegawa; K Takazoe; N Katoh; H Hayakawa; N Osaka; H Yamamoto; A Ogawa; H Kubo; T Shigematsu; O Sakai; S Horiuchi Journal: Kidney Int Date: 1997-01 Impact factor: 10.612
Authors: Rafael Selgas; M Auxiliadora Bajo; Antonio Cirugeda; Gloria del Peso; Jorge Valdés; M José Castro; Sonia Sánchez; M José Fernández-Reyes; Covadonga Hevia; Fernando Gil; Abelardo Aguilera; Javier Ortiz; Laura Alegre; Vicente Alvarez; J Antonio Sánchez-Tomero Journal: Perit Dial Int Date: 2005 Jan-Feb Impact factor: 1.756
Authors: K Scott Brimble; Michelle Walker; Peter J Margetts; Kiran K Kundhal; Christian G Rabbat Journal: J Am Soc Nephrol Date: 2006-08-02 Impact factor: 10.121
Authors: W K Lo; A Brendolan; B F Prowant; H L Moore; R Khanna; Z J Twardowski; K D Nolph Journal: J Am Soc Nephrol Date: 1994-01 Impact factor: 10.121
Authors: Simon J Davies; Edwina A Brown; Niels E Frandsen; Anabela S Rodrigues; Ana Rodriguez-Carmona; Andreas Vychytil; Evelyne Macnamara; Agneta Ekstrand; Anders Tranaeus; Jose C Divino Filho Journal: Kidney Int Date: 2005-04 Impact factor: 10.612
Authors: Gloria del Peso; María José Fernández-Reyes; Covadonga Hevia; María Auxiliadora Bajo; María José Castro; Antonio Cirugeda; José Antonio Sánchez-Tomero; Rafael Selgas Journal: Nephrol Dial Transplant Date: 2005-04-12 Impact factor: 5.992