| Literature DB >> 22472456 |
Rulin C Hechter1, Matthew Budoff, Howard N Hodis, Charles R Rinaldo, Frank J Jenkins, Lisa P Jacobson, Lawrence A Kingsley, Babafemi Taiwo, Wendy S Post, Joseph B Margolick, Roger Detels.
Abstract
We assessed associations of herpes simplex virus types 1 and 2 (HSV-1 and -2), cytomegalovirus (CMV), and human herpesvirus 8 (HHV-8) infection with subclinical coronary atherosclerosis in 291 HIV-infected men in the Multicenter AIDS Cohort Study. Coronary artery calcium (CAC) was measured by non-contrast coronary CT imaging. Markers for herpesviruses infection were measured in frozen specimens collected 10-12 years prior to case identification. Multivariable logistic regression models and ordinal logistic regression models were performed. HSV-2 seropositivity was associated with coronary atherosclerosis (adjusted odds ratio [AOR]=4.12, 95% confidence interval [CI]=1.58-10.85) after adjustment for age, race/ethnicity, cardiovascular risk factors, and HIV infection related factors. Infection with a greater number of herpesviruses was associated with elevated CAC levels (AOR=1.58, 95% CI=1.06-2.36). Our findings suggest HSV-2 may be a risk factor for subclinical coronary atherosclerosis in HIV-infected men. Infection with multiple herpesviruses may contribute to the increased burden of atherosclerosis.Entities:
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Year: 2012 PMID： 22472456 PMCID： PMC3392500 DOI： 10.1016/j.atherosclerosis.2012.03.002
Source DB: PubMed Journal: Atherosclerosis ISSN： 0021-9150 Impact factor: 5.162