BACKGROUND: Turner Syndrome women are at high risk of vascular disease and the assessment of early risk factors in Turner Syndrome girls is an emerging focus of research. Our objective was to evaluate endothelial function (EF), a preclinical measure of atherosclerosis, in Turner Syndrome girls compared with controls. METHODS: A cross-sectional case-control study of Turner Syndrome girls and healthy controls. Subjects underwent fasting insulin and glucose with calculation of HOMA-IR, fasting lipid profile, anthropometrics, and EF testing using peripheral arterial tonometry (PAT). Subjects, aged 10-18 years, had karyotype-confirmed Turner Syndrome; growth hormone (GH), thyroxine and estrogen use were not exclusion criteria. Controls were age- and BMI-matched healthy girls. Fifteen Turner Syndrome and 15 controls were recruited. RESULTS: Turner Syndrome girls had lower height, higher HDL and higher waist:height ratio than controls. PAT-hyperemia ratio (RH-PAT) scores were lower in Turner Syndrome (1.64 ± 0.34 vs. 2.08 ± 0.32, p = 0.002) indicating impaired EF. Among Turner Syndrome, RH-PAT did not vary with estrogen therapy or with karyotype 45,XO compared with other karyotypes. However, endothelial function was better in GH-treated compared with GH-untreated Turner Syndrome (1.80 ± 0.36 vs. 1.4 + 0.22, p = 0.02) although there were no differences in HOMA-IR, adiponectin or IGF-1. CONCLUSION: Girls with Turner Syndrome exhibit impaired endothelial function compared with controls, which may explain higher risk for vascular disease. GH may protect endothelial function in Turner Syndrome.
BACKGROUND:Turner Syndromewomen are at high risk of vascular disease and the assessment of early risk factors in Turner Syndromegirls is an emerging focus of research. Our objective was to evaluate endothelial function (EF), a preclinical measure of atherosclerosis, in Turner Syndromegirls compared with controls. METHODS: A cross-sectional case-control study of Turner Syndromegirls and healthy controls. Subjects underwent fasting insulin and glucose with calculation of HOMA-IR, fasting lipid profile, anthropometrics, and EF testing using peripheral arterial tonometry (PAT). Subjects, aged 10-18 years, had karyotype-confirmed Turner Syndrome; growth hormone (GH), thyroxine and estrogen use were not exclusion criteria. Controls were age- and BMI-matched healthy girls. Fifteen Turner Syndrome and 15 controls were recruited. RESULTS:Turner Syndromegirls had lower height, higher HDL and higher waist:height ratio than controls. PAT-hyperemia ratio (RH-PAT) scores were lower in Turner Syndrome (1.64 ± 0.34 vs. 2.08 ± 0.32, p = 0.002) indicating impaired EF. Among Turner Syndrome, RH-PAT did not vary with estrogen therapy or with karyotype 45,XO compared with other karyotypes. However, endothelial function was better in GH-treated compared with GH-untreated Turner Syndrome (1.80 ± 0.36 vs. 1.4 + 0.22, p = 0.02) although there were no differences in HOMA-IR, adiponectin or IGF-1. CONCLUSION:Girls with Turner Syndrome exhibit impaired endothelial function compared with controls, which may explain higher risk for vascular disease. GH may protect endothelial function in Turner Syndrome.
Authors: J T Kuvin; A R Patel; K A Sliney; N G Pandian; W M Rand; J E Udelson; R H Karas Journal: J Am Coll Cardiol Date: 2001-12 Impact factor: 24.094
Authors: S Caprio; S Boulware; M Diamond; R S Sherwin; T O Carpenter; K Rubin; S Amiel; M Press; W V Tamborlane Journal: J Clin Endocrinol Metab Date: 1991-04 Impact factor: 5.958
Authors: Mikko J Järvisalo; Anne Putto-Laurila; Laura Jartti; Terho Lehtimäki; Tiina Solakivi; Tapani Rönnemaa; Olli T Raitakari Journal: Diabetes Date: 2002-02 Impact factor: 9.461
Authors: T J Anderson; A Uehata; M D Gerhard; I T Meredith; S Knab; D Delagrange; E H Lieberman; P Ganz; M A Creager; A C Yeung Journal: J Am Coll Cardiol Date: 1995-11-01 Impact factor: 24.094
Authors: S Caprio; S D Boulware; M Press; R S Sherwin; K Rubin; T O Carpenter; G Plewe; W V Tamborlane Journal: J Pediatr Date: 1992-02 Impact factor: 4.406
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