BACKGROUND: Our aim was to investigate the relationship between frailty and health-related quality of life (HR-QOL) in cognitively impaired elderly individuals. METHODS: A cross-sectional observational study of a convenience sample of 115 patients with a diagnosis of Alzheimer's dementia or mild cognitive impairment. Frailty was measured using the biological syndrome model and HR-QOL was measured using the DEMQOL-Proxy. Regression models were constructed to establish the factors associated with HR-QOL. RESULTS: Frailty and neuropsychiatric symptoms were associated with HR-QOL, with Mini-Mental State Examination (MMSE) scores ≥21 (P = .037, P ≤ .001, and R (2) = .362). Functional limitation was associated with HR-QOL, with MMSE scores ≤20 (P = .017 and R (2) = .377). CONCLUSION: Frailty and neuropsychiatric symptoms were the determinants of HR-QOL in the earlier stages of cognitive impairment. Functional limitation predicted HR-QOL in the later stages of cognitive impairment. Frailty may represent a novel modifiable target in early dementia to improve HR-QOL for patients.
BACKGROUND: Our aim was to investigate the relationship between frailty and health-related quality of life (HR-QOL) in cognitively impaired elderly individuals. METHODS: A cross-sectional observational study of a convenience sample of 115 patients with a diagnosis of Alzheimer's dementia or mild cognitive impairment. Frailty was measured using the biological syndrome model and HR-QOL was measured using the DEMQOL-Proxy. Regression models were constructed to establish the factors associated with HR-QOL. RESULTS: Frailty and neuropsychiatric symptoms were associated with HR-QOL, with Mini-Mental State Examination (MMSE) scores ≥21 (P = .037, P ≤ .001, and R (2) = .362). Functional limitation was associated with HR-QOL, with MMSE scores ≤20 (P = .017 and R (2) = .377). CONCLUSION: Frailty and neuropsychiatric symptoms were the determinants of HR-QOL in the earlier stages of cognitive impairment. Functional limitation predicted HR-QOL in the later stages of cognitive impairment. Frailty may represent a novel modifiable target in early dementia to improve HR-QOL for patients.
Authors: Eduardo L Cadore; Alvaro Casas-Herrero; Fabricio Zambom-Ferraresi; Alicia Martínez-Ramírez; Nora Millor; Marisol Gómez; Ana B Bays Moneo; Mikel Izquierdo Journal: Age (Dordr) Date: 2015-12-14
Authors: Eduardo L Cadore; Ana B Bays Moneo; Marta Martinez Mensat; Andrea Rozas Muñoz; Alvaro Casas-Herrero; Leocadio Rodriguez-Mañas; Mikel Izquierdo Journal: Age (Dordr) Date: 2013-11-16
Authors: Kate E Devenney; Marit L Sanders; Brian Lawlor; Marcel G M Olde Rikkert; Stefan Schneider Journal: BMC Geriatr Date: 2017-03-22 Impact factor: 3.921
Authors: Ana Rodriguez-Larrad; Haritz Arrieta; Chloe Rezola; Maider Kortajarena; Jose Javier Yanguas; Miren Iturburu; María Gil Susana; Jon Irazusta Journal: BMC Geriatr Date: 2017-02-23 Impact factor: 3.921
Authors: Leonie C P Banning; Eveline P C J Janssen; Renske E G Hamel; Marjolein de Vugt; Sebastian Köhler; Claire A G Wolfs; Saskia M Oosterveld; Rene J F Melis; Marcel G M Olde Rikkert; Roy P C Kessels; Yolande A L Pijnenburg; Ted Koene; Wiesje M van der Flier; Philip Scheltens; Pieter Jelle Visser; Frans R J Verhey; Pauline Aalten; Inez H G B Ramakers Journal: J Geriatr Psychiatry Neurol Date: 2019-10-23 Impact factor: 2.680