BACKGROUND: The early detection of osteonecrosis of the femoral head (ONFH) is difficult, but important for prevention of destruction of the femoral head. The objective of this study was to determine whether the occurrence of osteonecrosis of the femoral head (ONFH) correlates with changes in bone turnover markers. METHODS: In 40 patients undergoing primary total hip arthroplasty (THA), different bone turnover markers and hormones (bone specific alkaline phosphatase, osteocalcin, beta cross-laps, 25-hydroxy-cholecalciferol, and parathormone) gained from blood were determined on the morning of the surgery. Twenty-two patients needed a THA due to progressed ONFH. In 18 cases blood was gained from patients with the indication for a THA given due to advanced osteoarthritis (AO) of the hip. RESULTS: Bone specific alkaline phosphatase, osteocalcin, beta cross-laps, and parathormone did not show any deviation from standard values, neither for the group of osteonecrosis nor for the osteoarthritis group. 25-Hydroxy-cholecalciferol revealed on average decreased values without significant differences between both groups (P < 0.05). The tested bone turnover markers and hormones failed to predict the occurrence of ONFH. Thus, the focus has to be put on different parameters to find a specific parameter that possibly predicts the risk of ostenecrosis and that is suited to follow up ONFH.
BACKGROUND: The early detection of osteonecrosis of the femoral head (ONFH) is difficult, but important for prevention of destruction of the femoral head. The objective of this study was to determine whether the occurrence of osteonecrosis of the femoral head (ONFH) correlates with changes in bone turnover markers. METHODS: In 40 patients undergoing primary total hip arthroplasty (THA), different bone turnover markers and hormones (bone specific alkaline phosphatase, osteocalcin, beta cross-laps, 25-hydroxy-cholecalciferol, and parathormone) gained from blood were determined on the morning of the surgery. Twenty-two patients needed a THA due to progressed ONFH. In 18 cases blood was gained from patients with the indication for a THA given due to advanced osteoarthritis (AO) of the hip. RESULTS: Bone specific alkaline phosphatase, osteocalcin, beta cross-laps, and parathormone did not show any deviation from standard values, neither for the group of osteonecrosis nor for the osteoarthritis group. 25-Hydroxy-cholecalciferol revealed on average decreased values without significant differences between both groups (P < 0.05). The tested bone turnover markers and hormones failed to predict the occurrence of ONFH. Thus, the focus has to be put on different parameters to find a specific parameter that possibly predicts the risk of ostenecrosis and that is suited to follow up ONFH.
Authors: A C Looker; D C Bauer; C H Chesnut; C M Gundberg; M C Hochberg; G Klee; M Kleerekoper; N B Watts; N H Bell Journal: Osteoporos Int Date: 2000 Impact factor: 4.507
Authors: Konstantinos Z Vlasiadis; John Damilakis; George A Velegrakis; Chris A Skouteris; Ivoni Fragouli; Anastasia Goumenou; John Matalliotakis; Eugenios E Koumantakis Journal: Maturitas Date: 2008-03-14 Impact factor: 4.342
Authors: Andrew Gordon; Lorraine Southam; John Loughlin; Anthony Gerard Wilson; Ian Stockley; Andrew J Hamer; Richard Eastell; Jeremy Mark Wilkinson Journal: J Orthop Res Date: 2007-12 Impact factor: 3.494