Samuel L Oyer1, Valerie A Smith, Eric J Lentsch. 1. Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina 29425-5500, USA.
Abstract
OBJECTIVE: To determine the impact of age on disease-specific survival in differentiated thyroid cancer. STUDY DESIGN: Retrospective analysis of a large population database. Setting Surveillance, Epidemiology, and End Results (SEER) database/multiple settings. SUBJECTS AND METHODS: The SEER database was examined to identify patients diagnosed with either papillary or follicular carcinoma of the thyroid between the years 1988 and 2003. Information obtained included patient age, sex, tumor type, size, extension, and nodal or distant metastases. Kaplan-Meier survival analyses were used to estimate disease-specific survival based on patient age range, and the log-rank test was used to assess for statistical differences between survival curves. A multivariate analysis was performed including the variables listed above to determine disease-specific hazard ratios of death for various age cutoffs. RESULTS: A total of 42,209 patients were identified. Patients 45 years and older had significantly worse survival than younger patients (P < .0001). A significant decrease in disease-specific survival was first seen in patients aged 35 years and older, and survival continued to steadily decrease with each additional decade of age (P < .001). Patients aged 35 years and older were 14 times more likely to die from differentiated thyroid cancer than patients younger than 35 years. CONCLUSION: Increasing age is associated with poorer survival in differentiated thyroid cancer. This relationship represents a continuum with an initial decrease in survival starting at age 35 years that continues to decline with further advancing age.
OBJECTIVE: To determine the impact of age on disease-specific survival in differentiated thyroid cancer. STUDY DESIGN: Retrospective analysis of a large population database. Setting Surveillance, Epidemiology, and End Results (SEER) database/multiple settings. SUBJECTS AND METHODS: The SEER database was examined to identify patients diagnosed with either papillary or follicular carcinoma of the thyroid between the years 1988 and 2003. Information obtained included patient age, sex, tumor type, size, extension, and nodal or distant metastases. Kaplan-Meier survival analyses were used to estimate disease-specific survival based on patient age range, and the log-rank test was used to assess for statistical differences between survival curves. A multivariate analysis was performed including the variables listed above to determine disease-specific hazard ratios of death for various age cutoffs. RESULTS: A total of 42,209 patients were identified. Patients 45 years and older had significantly worse survival than younger patients (P < .0001). A significant decrease in disease-specific survival was first seen in patients aged 35 years and older, and survival continued to steadily decrease with each additional decade of age (P < .001). Patients aged 35 years and older were 14 times more likely to die from differentiated thyroid cancer than patients younger than 35 years. CONCLUSION: Increasing age is associated with poorer survival in differentiated thyroid cancer. This relationship represents a continuum with an initial decrease in survival starting at age 35 years that continues to decline with further advancing age.
Authors: Ryan K Orosco; Timon Hussain; Kevin T Brumund; Deborah K Oh; David C Chang; Michael Bouvet Journal: Thyroid Date: 2015-01 Impact factor: 6.568
Authors: Iain J Nixon; Laura Y Wang; Jocelyn C Migliacci; Antoine Eskander; Michael J Campbell; Ahmad Aniss; Lilah Morris; Fernanda Vaisman; Rossana Corbo; Denise Momesso; Mario Vaisman; Andre Carvalho; Diana Learoyd; William D Leslie; Richard W Nason; Deborah Kuk; Volkert Wreesmann; Luc Morris; Frank L Palmer; Ian Ganly; Snehal G Patel; Bhuvanesh Singh; R Michael Tuttle; Ashok R Shaha; Mithat Gönen; K Alok Pathak; Wen T Shen; Mark Sywak; Luis Kowalski; Jeremy Freeman; Nancy Perrier; Jatin P Shah Journal: Thyroid Date: 2016-02-25 Impact factor: 6.568
Authors: Ian Ganly; Iain J Nixon; Laura Y Wang; Frank L Palmer; Jocelyn C Migliacci; Ahmad Aniss; Mark Sywak; Antoine E Eskander; Jeremy L Freeman; Michael J Campbell; Wen T Shen; Fernanda Vaisman; Denise Momesso; Rossana Corbo; Mario Vaisman; Ashok Shaha; R Michael Tuttle; Jatin P Shah; Snehal G Patel Journal: Thyroid Date: 2015-08-12 Impact factor: 6.568
Authors: Iain J Nixon; Deborah Kuk; Volkert Wreesmann; Luc Morris; Frank L Palmer; Ian Ganly; Snehal G Patel; Bhuvanesh Singh; R Michael Tuttle; Ashok R Shaha; Mithat Gönen; Jatin P Shah Journal: Ann Surg Oncol Date: 2015-07-28 Impact factor: 5.344