Role of estrogens in pathogenesis of age-related disease in women of menopausal age.

The aim of our study was to determine the influence of estrogen on the intensity of oxidative metabolism in women of reproductive and menopausal age. Two groups of women - less than 45 years old (reproductive age) and more than 45 years old (menopausal age) were investigated. In each group we investigated the estradiole, fibrinogen, ALT, oxygen (O(2)(-)) and lipid (LOO·) reactive spesies, NO content, antioxidant enzymes (SOD, catalase, GR) activity. It was reviealed nondirect corelation between development of inflammation, hypoxia and estrogen content in the blood of women without genetic predisponce to alterations of lipid metabolism. Subsequently in reproductive age they are developed usually against hypoestrogenomia; however the physiological reduction in estrogen levels during menopause by itself contributes to impairment of metabolism and intensification of inflammation (inflammatory markers CPR, ALT), oxidative stress (O(2)(-), LOO·), hipoxia (HBNO) and all related compititions (increase vascular resistence, disorders in oxygen suplay in tissue and hypoxic compititions of there metabolism). All this may cause, postmenopausal hypertension, hart ischemis disease, impaired hepatic beta-oxidation of fatty acids and hepathosteatosis. In women with genetic predisponce to dislipidemia the estrogen-related factors are less important in pathogenesis of age-related diseases.