BACKGROUND: The prevention of otitis media, particularly among infants, remains a controversial issue. We evaluated the efficacy of insertion of tympanostomy tubes with and without adenoidectomy for preventing recurrent acute otitis media (AOM) in young children. METHODS: We randomly assigned 300 children aged 10 months to 2 years who had recurrent AOM to groups receivingtympanostomy tubes (Tymp) (n = 100), tympanostomy tubes with adenoidectomy (TympAde) (n = 100) or neither (Contr) (n = 100). All the children were followed up for 12 months. RESULTS: The primary outcome was intervention failure (2 AOM episodes in 2 months, 3 in 6 months or persistent effusion lasting for 2 months). Intervention failed in 21% of cases (21/100) in the Tymp group, 16% (16/100) in the TympAde group and 34% (34/100) in the Contr group. The absolute differences were -13% [95% confidence interval (CI) -25% to -1%, P = 0.04] between the Tymp and Contr groups and -18% (95% CI -30 to -6%, P =0.004) between the TympAde and Contr groups. CONCLUSIONS: Insertion of tympanostomy tubes alone or with adenoidectomy was effective in preventing recurrent AOM episodes in children younger than 2 years of age.
RCT Entities:
BACKGROUND: The prevention of otitis media, particularly among infants, remains a controversial issue. We evaluated the efficacy of insertion of tympanostomy tubes with and without adenoidectomy for preventing recurrent acute otitis media (AOM) in young children. METHODS: We randomly assigned 300 children aged 10 months to 2 years who had recurrent AOM to groups receiving tympanostomy tubes (Tymp) (n = 100), tympanostomy tubes with adenoidectomy (TympAde) (n = 100) or neither (Contr) (n = 100). All the children were followed up for 12 months. RESULTS: The primary outcome was intervention failure (2 AOM episodes in 2 months, 3 in 6 months or persistent effusion lasting for 2 months). Intervention failed in 21% of cases (21/100) in the Tymp group, 16% (16/100) in the TympAde group and 34% (34/100) in the Contr group. The absolute differences were -13% [95% confidence interval (CI) -25% to -1%, P = 0.04] between the Tymp and Contr groups and -18% (95% CI -30 to -6%, P =0.004) between the TympAde and Contr groups. CONCLUSIONS: Insertion of tympanostomy tubes alone or with adenoidectomy was effective in preventing recurrent AOM episodes in children younger than 2 years of age.
Authors: Tal Marom; Alai Tan; Gregg S Wilkinson; Karen S Pierson; Jean L Freeman; Tasnee Chonmaitree Journal: JAMA Pediatr Date: 2014-01 Impact factor: 16.193
Authors: Alejandro Hoberman; Diego Preciado; Jack L Paradise; David H Chi; MaryAnn Haralam; Stan L Block; Diana H Kearney; Sonika Bhatnagar; Gysella B Muñiz Pujalt; Timothy R Shope; Judith M Martin; Daniel E Felten; Marcia Kurs-Lasky; Hui Liu; Kristin Yahner; Jong-Hyeon Jeong; Norman L Cohen; Brian Czervionke; Jennifer P Nagg; Joseph E Dohar; Nader Shaikh Journal: N Engl J Med Date: 2021-05-13 Impact factor: 91.245
Authors: Edoardo Bernkopf; Andrea Lovato; Giulia Bernkopf; Luciano Giacomelli; Giovanni Carlo De Vincentis; Francesco Macrì; Cosimo de Filippis Journal: Biomed Res Int Date: 2016-11-14 Impact factor: 3.411