| Literature DB >> 22465504 |
Muhammad Afzal1, Gaurav Gupta, Imran Kazmi, Mahfoozur Rahman, Obaid Afzal, Jahangir Alam, Khalidur Rahman Hakeem, Mohammad Pravez, Ritu Gupta, Firoz Anwar.
Abstract
A new steroidal derivative, urs Stigmast-4, 20 (21), 23-trien-3-one and other four compounds were isolated from the leaves of Bryophyllum pinnatum. The structure of this new steroid was elucidated and established by standard spectroscopic methods. Carrageenan induced paw edema model was used for anti-inflammatory and acetic acid induced model used for analgesic activity. This new steroidal compound was found to be active in reducing inflammation (% inhibition 87.29 and 84.45 respectively) when compared with diclofenac. Further, it showed 75.72% protection in analgesic activity in acetic acid induced writhing test in mice. In conclusion the % inhibition against carrageenan induced rat paw edema and % protection against acetic acid induced writhings showed by new compound revealed that the anti-inflammatory and analgesic activity of aqueous extract B. pinnatum are mainly due to the presence of this steroidal compound. CrownEntities:
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Year: 2012 PMID： 22465504 DOI： 10.1016/j.fitote.2012.03.013
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882