Literature DB >> 224652

Transformation of hamster embryonic fibroblast cells by UV-irradiated human cytomegalovirus.

I Boldogh, E Gönczöl, L Váczi.   

Abstract

Infection of hamster embryonic fibroblast (HEF) cells with UV-irradiated human CMV resulted in appearance of transformed clones. The established cell line (87-TRH-5) when inoculated subcutaneously induced tumour in newborn hamsters. The 87-TRH-5 cell line and the cell lines (87-TRH-5-Tsc1, 87-TRH-5-Tsc2, 87TRH-5-Tsc3) developed from the induced tumour, proved to bear CMV-spcific cytoplasmic and surface antigens. Demonstration of infectious CMV or MCV-specific nuclear antigen in 87-THR-5-cells has failed.

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Year:  1978        PMID： 224652

Source DB:  PubMed          Journal:  Acta Microbiol Acad Sci Hung        ISSN： 0001-6187


  6 in total

Review 1.  Human cytomegalovirus and human herpesvirus 6 genes that transform and transactivate.

Authors:  J Doniger; S Muralidhar; L J Rosenthal
Journal:  Clin Microbiol Rev       Date:  1999-07       Impact factor: 26.132

2.  Human cytomagalovirus IE1 and IE2 proteins are mutagenic and mediate "hit-and-run" oncogenic transformation in cooperation with the adenovirus E1A proteins.

Authors:  Y Shen; H Zhu; T Shenk
Journal:  Proc Natl Acad Sci U S A       Date:  1997-04-01       Impact factor: 11.205

3.  Human cytomegalovirus elevates levels of the cellular protein p53 in infected fibroblasts.

Authors:  P Muganda; O Mendoza; J Hernandez; Q Qian
Journal:  J Virol       Date:  1994-12       Impact factor: 5.103

4.  Vesicular stomatitis virus pseudotypes produced by cells abortively infected or transformed by human cytomegalovirus.

Authors:  E Gönczöl; I Boldogh; L Váczi
Journal:  Arch Virol       Date:  1980       Impact factor: 2.574

5.  Lack of association of cytomegalovirus with adenocarcinoma of the colon.

Authors:  H Hart; W A Neill; M Norval
Journal:  Gut       Date:  1982-01       Impact factor: 23.059

6.  Characterization of guinea pig cytomegalovirus DNA.

Authors:  H C Isom; M Gao; B Wigdahl
Journal:  J Virol       Date:  1984-02       Impact factor: 5.103
  6 in total

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