Cohort mortality study of roofing granule mine and mill workers. Part I: Estimation of historical crystalline silica exposures.

A study was conducted to construct a job exposure matrix for the roofing granule mine and mill workers at four U.S. plants. Each plant mined different minerals and had unique departments and jobs. The goal of the study was to generate accurate estimates of the mean exposure to respirable crystalline silica for each cell of the job exposure matrix, that is, every combination of plant, department, job, and year represented in the job histories of the study participants. The objectives of this study were to locate, identify, and collect information on all exposure measurements ever collected at each plant, statistically analyze the data to identify deficiencies in the database, identify and resolve questionable measurements, identify all important process and control changes for each plant-department-job combination, construct a time line for each plant-department combination indicating periods where the equipment and conditions were unchanged, and finally, construct a job exposure matrix. After evaluation, 1871 respirable crystalline silica measurements and estimates remained. The primary statistic of interest was the mean exposure for each job exposure matrix cell. The average exposure for each of the four plants was 0.042 mg/m(3) (Belle Mead, N.J.), 0.106 mg/m(3) (Corona, Calif.), 0.051 mg/m(3) (Little Rock, Ark.), and 0.152 mg/m(3) (Wausau, Wis.), suggesting that there may be substantial differences in the employee cumulative exposures. Using the database and the available plant information, the study team assigned an exposure category and mean exposure for every plant-department-job and time interval combination. Despite a fairly large database, the mean exposure for > 95% of the job exposure matrix cells, or specific plant-department-job-year combinations, were estimated by analogy to similar jobs in the plant for which sufficient data were available. This approach preserved plant specificity, hopefully improving the usefulness of the job exposure matrix.