Literature DB >> 22462051

Neuroprotective effect of GK-2, a dipeptide mimetic of nerve growth factor, during experimental focal ischemia in middle cerebral artery basin.

S B Seredenin1, D N Silachev, T A Gudasheva, Yu A Pirogov, N K Isaev.   

Abstract

Magnetic resonance tomography, staining with triphenyltetrazolium chloride, and tests for evaluation of functional disturbances "cylinder" and "limb stimulation" showed that daily intraperitoneal injection of dipeptide mimetic of nerve growth factor GK-2 (1 mg/kg) for 6 days to rats with experimental focal ischemia provoked by unilateral intravascular occlusion of a branch of the middle cerebral artery significantly improved neurological deficit and decreased the infarction area.

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Year:  2011        PMID： 22462051     DOI： 10.1007/s10517-011-1388-7

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  4 in total

1.  Low-Molecular-Weight Perorally Active Nerve Growth Factor Mimetic Reduces Manifestations of Diabetic Neuropathy in Wistar Rats.

Authors:  S V Ivanov; R U Ostrovskaya; A S Khlybova; T A Gudasheva
Journal:  Bull Exp Biol Med       Date:  2022-05-27       Impact factor: 0.804

2.  Mimetics of brain-derived neurotrophic factor loops 1 and 4 are active in a model of ischemic stroke in rats.

Authors:  Tatyana A Gudasheva; Polina Povarnina; Ilya O Logvinov; Tatyana A Antipova; Sergey B Seredenin
Journal:  Drug Des Devel Ther       Date:  2016-11-02       Impact factor: 4.162

3.  Dimeric dipeptide mimetics of the nerve growth factor Loop 4 and Loop 1 activate TRKA with different patterns of intracellular signal transduction.

Authors:  Tatyana A Gudasheva; Polina Yu Povarnina; Tatyana A Antipova; Yulia N Firsova; Mark A Konstantinopolsky; Sergey B Seredenin
Journal:  J Biomed Sci       Date:  2015-12-08       Impact factor: 8.410

Review 4.  Novel Technologies for Dipeptide Drugs Design and their Implantation.

Authors:  Tatiana A Gudasheva; Rita U Ostrovskaya; Sergey B Seredenin
Journal:  Curr Pharm Des       Date:  2018       Impact factor: 3.116
  4 in total

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