Literature DB >> 22461639

Pluripotent stem cell-based cancer therapy: promise and challenges.

Saul J Sharkis1, Richard J Jones, Curt Civin, Yoon-Young Jang.   

Abstract

The development of induced pluripotent stem cell (iPSC) technology has generated enthusiasm about the therapeutic potential of these cells for treating a variety of diseases. However, the evidence that they actually will be clinically useful is limited. Here, we discuss the potential therapeutic applications of iPSCs for treating cancer and other diseases and highlight the current barriers restricting their use.

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Year:  2012        PMID： 22461639      PMCID： PMC3397797          DOI： 10.1126/scitranslmed.3003920

Source DB:  PubMed          Journal:  Sci Transl Med        ISSN： 1946-6234            Impact factor:   17.956


  37 in total

1.  Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells.

Authors:  Jose M Polo; Susanna Liu; Maria Eugenia Figueroa; Warakorn Kulalert; Sarah Eminli; Kah Yong Tan; Effie Apostolou; Matthias Stadtfeld; Yushan Li; Toshi Shioda; Sridaran Natesan; Amy J Wagers; Ari Melnick; Todd Evans; Konrad Hochedlinger
Journal:  Nat Biotechnol       Date:  2010-07-19       Impact factor: 54.908

2.  Outcomes of pediatric bone marrow transplantation for leukemia and myelodysplasia using matched sibling, mismatched related, or matched unrelated donors.

Authors:  Peter J Shaw; Fangyu Kan; Kwang Woo Ahn; Stephen R Spellman; Mahmoud Aljurf; Mouhab Ayas; Michael Burke; Mitchell S Cairo; Allen R Chen; Stella M Davies; Haydar Frangoul; James Gajewski; Robert Peter Gale; Kamar Godder; Gregory A Hale; Martin B A Heemskerk; John Horan; Naynesh Kamani; Kimberly A Kasow; Ka Wah Chan; Stephanie J Lee; Wing H Leung; Victor A Lewis; David Miklos; Machteld Oudshoorn; Effie W Petersdorf; Olle Ringdén; Jean Sanders; Kirk R Schultz; Adriana Seber; Michelle Setterholm; Donna A Wall; Lolie Yu; Michael A Pulsipher
Journal:  Blood       Date:  2010-07-29       Impact factor: 22.113

3.  Reprogramming of human peripheral blood cells to induced pluripotent stem cells.

Authors:  Judith Staerk; Meelad M Dawlaty; Qing Gao; Dorothea Maetzel; Jacob Hanna; Cesar A Sommer; Gustavo Mostoslavsky; Rudolf Jaenisch
Journal:  Cell Stem Cell       Date:  2010-07-02       Impact factor: 24.633

4.  Reprogramming of T cells from human peripheral blood.

Authors:  Yuin-Han Loh; Odelya Hartung; Hu Li; Chunguang Guo; Julie M Sahalie; Philip D Manos; Achia Urbach; Garrett C Heffner; Marica Grskovic; Francois Vigneault; M William Lensch; In-Hyun Park; Suneet Agarwal; George M Church; James J Collins; Stefan Irion; George Q Daley
Journal:  Cell Stem Cell       Date:  2010-07-02       Impact factor: 24.633

5.  Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells.

Authors:  S Tamir Rashid; Sebastien Corbineau; Nick Hannan; Stefan J Marciniak; Elena Miranda; Graeme Alexander; Isabel Huang-Doran; Julian Griffin; Lars Ahrlund-Richter; Jeremy Skepper; Robert Semple; Anne Weber; David A Lomas; Ludovic Vallier
Journal:  J Clin Invest       Date:  2010-08-25       Impact factor: 14.808

6.  T-cell receptor-driven lymphomagenesis in mice derived from a reprogrammed T cell.

Authors:  Thomas Serwold; Konrad Hochedlinger; John Swindle; Joe Hedgpeth; Rudolf Jaenisch; Irving L Weissman
Journal:  Proc Natl Acad Sci U S A       Date:  2010-10-18       Impact factor: 11.205

7.  Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA.

Authors:  Luigi Warren; Philip D Manos; Tim Ahfeldt; Yuin-Han Loh; Hu Li; Frank Lau; Wataru Ebina; Pankaj K Mandal; Zachary D Smith; Alexander Meissner; George Q Daley; Andrew S Brack; James J Collins; Chad Cowan; Thorsten M Schlaeger; Derrick J Rossi
Journal:  Cell Stem Cell       Date:  2010-09-30       Impact factor: 24.633

Review 8.  Applications of patient-specific induced pluripotent stem cells; focused on disease modeling, drug screening and therapeutic potentials for liver disease.

Authors:  Yong Soon Chun; Pooja Chaudhari; Yoon-Young Jang
Journal:  Int J Biol Sci       Date:  2010-12-14       Impact factor: 6.580

9.  Somatic coding mutations in human induced pluripotent stem cells.

Authors:  Athurva Gore; Zhe Li; Ho-Lim Fung; Jessica E Young; Suneet Agarwal; Jessica Antosiewicz-Bourget; Isabel Canto; Alessandra Giorgetti; Mason A Israel; Evangelos Kiskinis; Je-Hyuk Lee; Yuin-Han Loh; Philip D Manos; Nuria Montserrat; Athanasia D Panopoulos; Sergio Ruiz; Melissa L Wilbert; Junying Yu; Ewen F Kirkness; Juan Carlos Izpisua Belmonte; Derrick J Rossi; James A Thomson; Kevin Eggan; George Q Daley; Lawrence S B Goldstein; Kun Zhang
Journal:  Nature       Date:  2011-03-03       Impact factor: 49.962

10.  Epigenetic memory in induced pluripotent stem cells.

Authors:  K Kim; A Doi; B Wen; K Ng; R Zhao; P Cahan; J Kim; M J Aryee; H Ji; L I R Ehrlich; A Yabuuchi; A Takeuchi; K C Cunniff; H Hongguang; S McKinney-Freeman; O Naveiras; T J Yoon; R A Irizarry; N Jung; J Seita; J Hanna; P Murakami; R Jaenisch; R Weissleder; S H Orkin; I L Weissman; A P Feinberg; G Q Daley
Journal:  Nature       Date:  2010-09-16       Impact factor: 49.962
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  19 in total

Review 1.  Expression kinetics of hepatic progenitor markers in cellular models of human liver development recapitulating hepatocyte and biliary cell fate commitment.

Authors:  Pooja Chaudhari; Lipeng Tian; Abhijeet Deshmukh; Yoon-Young Jang
Journal:  Exp Biol Med (Maywood)       Date:  2016-07-06

2.  A highly optimized protocol for reprogramming cancer cells to pluripotency using nonviral plasmid vectors.

Authors:  Hongzhi Zhao; Timothy J Davies; Jiaolin Ning; Yanxu Chang; Patty Sachamitr; Susanne Sattler; Paul J Fairchild; Fang-Ping Huang
Journal:  Cell Reprogram       Date:  2014-12-30       Impact factor: 1.987

3.  Thymic stromal lymphopoietin-mediated extramedullary hematopoiesis promotes allergic inflammation.

Authors:  Mark C Siracusa; Steven A Saenz; Elia D Tait Wojno; Brian S Kim; Lisa C Osborne; Carly G Ziegler; Alain J Benitez; Kathryn R Ruymann; Donna L Farber; Patrick M Sleiman; Hakon Hakonarson; Antonella Cianferoni; Mei-Lun Wang; Jonathan M Spergel; Michael R Comeau; David Artis
Journal:  Immunity       Date:  2013-12-12       Impact factor: 31.745

4.  Stem cells' guided gene therapy of cancer: New frontier in personalized and targeted therapy.

Authors:  Maria Mavroudi; Paul Zarogoulidis; Konstantinos Porpodis; Ioannis Kioumis; Sofia Lampaki; Lonny Yarmus; Raf Malecki; Konstantinos Zarogoulidis; Marek Malecki
Journal:  J Cancer Res Ther (Manch)       Date:  2014

5.  3D culturing of human pluripotent stem cells-derived endothelial cells for vascular regeneration.

Authors:  Edit Gara; Eleonora Zucchelli; Annamária Nemes; Zoltán Jakus; Kitti Ajtay; Éva Kemecsei; Gábor Kiszler; Nikolett Hegedűs; Krisztián Szigeti; Iván Földes; Kristóf Árvai; János Kósa; Kraszimir Kolev; Erzsébet Komorowicz; Parasuraman Padmanabhan; Pál Maurovich-Horvat; Edit Dósa; György Várady; Miklós Pólos; István Hartyánszky; Sian E Harding; Béla Merkely; Domokos Máthé; Gábor Szabó; Tamás Radovits; Gábor Földes
Journal:  Theranostics       Date:  2022-06-06       Impact factor: 11.600

6.  Efficient drug screening and gene correction for treating liver disease using patient-specific stem cells.

Authors:  Su Mi Choi; Yonghak Kim; Joong Sup Shim; Joon Tae Park; Rui-Hong Wang; Steven D Leach; Jun O Liu; Chuxia Deng; Zhaohui Ye; Yoon-Young Jang
Journal:  Hepatology       Date:  2013-06       Impact factor: 17.425

7.  Cell-based therapeutics: the next pillar of medicine.

Authors:  Michael A Fischbach; Jeffrey A Bluestone; Wendell A Lim
Journal:  Sci Transl Med       Date:  2013-04-03       Impact factor: 17.956

8.  Zinc finger nuclease-expressing baculoviral vectors mediate targeted genome integration of reprogramming factor genes to facilitate the generation of human induced pluripotent stem cells.

Authors:  Rui-Zhe Phang; Felix Chang Tay; Sal-Lee Goh; Cia-Hin Lau; Haibao Zhu; Wee-Kiat Tan; Qingle Liang; Can Chen; Shouhui Du; Zhendong Li; Johan Chin-Kang Tay; Chunxiao Wu; Jieming Zeng; Weimin Fan; Han Chong Toh; Shu Wang
Journal:  Stem Cells Transl Med       Date:  2013-10-28       Impact factor: 6.940

9.  Therapeutic effect of human iPS-cell-derived myeloid cells expressing IFN-β against peritoneally disseminated cancer in xenograft models.

Authors:  Chihiro Koba; Miwa Haruta; Yusuke Matsunaga; Keiko Matsumura; Eriko Haga; Yuko Sasaki; Tokunori Ikeda; Koutaro Takamatsu; Yasuharu Nishimura; Satoru Senju
Journal:  PLoS One       Date:  2013-06-24       Impact factor: 3.240

10.  Robust, microfabricated culture devices with improved control over the soluble microenvironment for the culture of embryonic stem cells.

Authors:  Rhys J Macown; Farlan S Veraitch; Nicolas Szita
Journal:  Biotechnol J       Date:  2014-04-23       Impact factor: 4.677
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