Literature DB >> 22460446

Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases.

Chong Liu1, Dingfeng Su.   

Abstract

Inflammation is important in the pathogenesis and development of cardiovascular diseases. Recent studies show that vagus nerve stimulation inhibits pro-inflammatory cytokine production through "the cholinergic anti-inflammatory pathway," more specifically via the α7 nicotinic acetylcholine receptor (α7nAChR). In the current study, the role of the cholinergic anti-inflammatory pathway during septic shock, hypertension, and myocardial infarction is reviewed, and its possible clinical implications in cardiovascular diseases are discussed.

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Year:  2012        PMID： 22460446     DOI： 10.1007/s11684-012-0171-0

Source DB:  PubMed          Journal:  Front Med        ISSN： 2095-0217            Impact factor:   4.592


  51 in total

1.  Vagus nerve stimulation inhibits activation of coagulation and fibrinolysis during endotoxemia in rats.

Authors:  D J van Westerloo; I A J Giebelen; J C M Meijers; J Daalhuisen; A F de Vos; M Levi; T van der Poll
Journal:  J Thromb Haemost       Date:  2006-06-29       Impact factor: 5.824

2.  Role of pulmonary vagal afferent nerve fibres in the development of rapid shallow breathing in lung inflammation.

Authors:  D Trenchard; D Gardner; A Guz
Journal:  Clin Sci       Date:  1972-03       Impact factor: 6.124

3.  Dysfunction of the cholinergic anti-inflammatory pathway mediates organ damage in hypertension.

Authors:  Dong-Jie Li; Roger G Evans; Zhong-Wei Yang; Shu-Wei Song; Pei Wang; Xiu-Juan Ma; Chong Liu; Tao Xi; Ding-Feng Su; Fu-Ming Shen
Journal:  Hypertension       Date:  2010-12-20       Impact factor: 10.190

Review 4.  The role of vagal function in the risk for cardiovascular disease and mortality.

Authors:  Julian F Thayer; Richard D Lane
Journal:  Biol Psychol       Date:  2006-12-19       Impact factor: 3.251

5.  Differential regulation of TNF receptors by vagal nerve stimulation protects heart against acute ischemic injury.

Authors:  Rajesh G Katare; Motonori Ando; Yoshihiko Kakinuma; Mikihiko Arikawa; Fumiyasu Yamasaki; Takayuki Sato
Journal:  J Mol Cell Cardiol       Date:  2010-03-17       Impact factor: 5.000

6.  Augmented input from cardiac sympathetic afferents inhibits baroreflex in rats with heart failure.

Authors:  Lie Gao; Harold D Schultz; Kaushik P Patel; Irving H Zucker; Wei Wang
Journal:  Hypertension       Date:  2005-05-16       Impact factor: 10.190

7.  Inflammation is involved in the organ damage induced by sinoaortic denervation in rats.

Authors:  Chuan Zhang; Hong Chen; He-Hui Xie; He Shu; Wen-Jun Yuan; Ding-Feng Su
Journal:  J Hypertens       Date:  2003-11       Impact factor: 4.844

8.  Transcutaneous vagus nerve stimulation reduces serum high mobility group box 1 levels and improves survival in murine sepsis.

Authors:  Jared M Huston; Margot Gallowitsch-Puerta; Mahendar Ochani; Kanta Ochani; Renqi Yuan; Mauricio Rosas-Ballina; Mala Ashok; Richard S Goldstein; Sangeeta Chavan; Valentin A Pavlov; Christine N Metz; Huan Yang; Christopher J Czura; Haichao Wang; Kevin J Tracey
Journal:  Crit Care Med       Date:  2007-12       Impact factor: 7.598

9.  Antishock effect of anisodamine involves a novel pathway for activating alpha7 nicotinic acetylcholine receptor.

Authors:  Chong Liu; Fu-Ming Shen; Ying-Ying Le; Yan Kong; Xia Liu; Guo-Jun Cai; Alex F Chen; Ding-Feng Su
Journal:  Crit Care Med       Date:  2009-02       Impact factor: 7.598

10.  Arterial baroreflex function determines the survival time in lipopolysaccharide-induced shock in rats.

Authors:  Fu-Ming Shen; Yun-Feng Guan; He-Hui Xie; Ding-Feng Su
Journal:  Shock       Date:  2004-06       Impact factor: 3.454
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  8 in total

1.  Activating α7 nicotinic acetylcholine receptor inhibits NLRP3 inflammasome through regulation of β-arrestin-1.

Authors:  Ping Ke; Bo-Zong Shao; Zhe-Qi Xu; Xiong-Wen Chen; Wei Wei; Chong Liu
Journal:  CNS Neurosci Ther       Date:  2017-09-21       Impact factor: 5.243

Review 2.  Novel strategies and underlying protective mechanisms of modulation of vagal activity in cardiovascular diseases.

Authors:  Xi He; Ming Zhao; Xueyuan Bi; Lei Sun; Xiaojiang Yu; Mei Zhao; Weijin Zang
Journal:  Br J Pharmacol       Date:  2015-01-13       Impact factor: 8.739

3.  Activation of Cholinergic Anti-Inflammatory Pathway Ameliorates Cerebral and Cardiac Dysfunction After Intracerebral Hemorrhage Through Autophagy.

Authors:  Yue Su; Wei Zhang; Ruoxi Zhang; Quan Yuan; Ruixia Wu; Xiaoxuan Liu; Jimusi Wuri; Ran Li; Tao Yan
Journal:  Front Immunol       Date:  2022-06-23       Impact factor: 8.786

4.  Short‑term vagal nerve stimulation improves left ventricular function following chronic heart failure in rats.

Authors:  Yan Li; Yan-Hua Xuan; Shuang-Shuang Liu; Jing Dong; Jia-Ying Luo; Zhi-Jun Sun
Journal:  Mol Med Rep       Date:  2015-04-07       Impact factor: 2.952

5.  Combined administration of anisodamine and neostigmine rescued acute lethal crush syndrome through α7nAChR-dependent JAK2-STAT3 signaling.

Authors:  Zhe-Qi Xu; Bo-Zong Shao; Ping Ke; Jian-Guo Liu; Guo-Ku Liu; Xiong-Wen Chen; Ding-Feng Su; Chong Liu
Journal:  Sci Rep       Date:  2016-11-22       Impact factor: 4.379

6.  Autophagy Plays an Important Role in Anti-inflammatory Mechanisms Stimulated by Alpha7 Nicotinic Acetylcholine Receptor.

Authors:  Bo-Zong Shao; Ping Ke; Zhe-Qi Xu; Wei Wei; Ming-He Cheng; Bin-Ze Han; Xiong-Wen Chen; Ding-Feng Su; Chong Liu
Journal:  Front Immunol       Date:  2017-05-16       Impact factor: 7.561

7.  Activation of Nicotinic Acetylcholine α7 Receptor Attenuates Progression of Monocrotaline-Induced Pulmonary Hypertension in Rats by Downregulating the NLRP3 Inflammasome.

Authors:  Yan Deng; Sheng-Lan Guo; Bin Wei; Xing-Cui Gao; Ying-Chuan Zhou; Jia-Quan Li
Journal:  Front Pharmacol       Date:  2019-02-26       Impact factor: 5.810

8.  Microarray-Based Comparisons of Ion Channel Expression Patterns: Human Keratinocytes to Reprogrammed hiPSCs to Differentiated Neuronal and Cardiac Progeny.

Authors:  Leonhard Linta; Marianne Stockmann; Qiong Lin; André Lechel; Christian Proepper; Tobias M Boeckers; Alexander Kleger; Stefan Liebau
Journal:  Stem Cells Int       Date:  2013-04-15       Impact factor: 5.443
  8 in total

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