OBJECTIVE: To verify the influence of visceral and subcutaneous fat, as well adipokines in bone mineral density (BMD) in obese adolescents. SUBJECTS AND METHODS: The study involved 125 postpubertal obese adolescents (45 boys and 80 girls). Anthropometric measurements, body composition, visceral and subcutaneous fat, and BMD were determined. Leptin, adiponectin, and insulin levels also analyzed. RESULTS: Data demonstrated a negative relationship between BMD with insulin resistance, visceral fat and leptin concentration; and bone mineral content with visceral/subcutaneous ratio. Positive association between BMD and subcutaneous fat was observed. CONCLUSIONS: Visceral fat and insulin resistance, as well as visceral/subcutaneous ratio and leptin concentration, were negative predictors of BMD in boys and girls, respectively. However, subcutaneous fat had a protective influence in BMD only in boys.
OBJECTIVE: To verify the influence of visceral and subcutaneous fat, as well adipokines in bone mineral density (BMD) in obese adolescents. SUBJECTS AND METHODS: The study involved 125 postpubertal obese adolescents (45 boys and 80 girls). Anthropometric measurements, body composition, visceral and subcutaneous fat, and BMD were determined. Leptin, adiponectin, and insulin levels also analyzed. RESULTS: Data demonstrated a negative relationship between BMD with insulin resistance, visceral fat and leptin concentration; and bone mineral content with visceral/subcutaneous ratio. Positive association between BMD and subcutaneous fat was observed. CONCLUSIONS: Visceral fat and insulin resistance, as well as visceral/subcutaneous ratio and leptin concentration, were negative predictors of BMD in boys and girls, respectively. However, subcutaneous fat had a protective influence in BMD only in boys.
Authors: Natalie A Glass; James C Torner; Elena M Letuchy; Trudy L Burns; Kathleen F Janz; Julie M Eichenberger Gilmore; Janet A Schlechte; Steven M Levy Journal: J Bone Miner Res Date: 2017-11-27 Impact factor: 6.741
Authors: Pouneh K Fazeli; Mark C Horowitz; Ormond A MacDougald; Erica L Scheller; Matthew S Rodeheffer; Clifford J Rosen; Anne Klibanski Journal: J Clin Endocrinol Metab Date: 2013-02-07 Impact factor: 5.958
Authors: Elodie Chaplais; Frédéric Dutheil; Geraldine Naughton; David Greene; Bruno Pereira; David Thivel; Daniel Courteix Journal: BMJ Open Date: 2016-10-18 Impact factor: 2.692
Authors: S Dalskov; C Ritz; A Larnkjær; C T Damsgaard; R A Petersen; L B Sørensen; K K Ong; A Astrup; K F Michaelsen; C Mølgaard Journal: Osteoporos Int Date: 2015-12-14 Impact factor: 4.507
Authors: Ismael Forte Freitas Júnior; Jefferson Rosa Cardoso; Diego G Destro Christofaro; Jamile Sanches Codogno; Augusto César Ferreira de Moraes; Rômulo Araújo Fernandes Journal: BMC Pediatr Date: 2013-03-20 Impact factor: 2.125