PURPOSE: To determine the clinical, epidemiological and prognostic factors of HIV-infected patients with influenza A H1N1 admitted to hospital. METHODS: The study population was HIV infected patients with confirmed influenza infection admitted to hospital in a multicenter cohort. We analyzed demographic data, comorbid conditions, severe events (bronchopneumonia, respiratory insufficiency, respiratory distress, sepsis, admission to intensive care unit, death) and outcome. Data were analyzed using descriptive statistics. Proportions were compared using the χ(2) test or Fisher exact test, when applicable. Quantitative variables were compared using the Student t test or Mann-Whitney test. Prognostic impact was analyzed using logistic regression. RESULTS: A total of 43 patients, of whom 62.8% were male, were included from 22 hospitals. The mean age was 43.3 years (interquartile range [IQR], 38.4-48.4). HIV was diagnosed for a mean of 14.5 years (IQR, 8.4-20.3). CD4 lymphocyte was <200 cells/μL in 38%; 85.7% were on antiretroviral therapy, and 66.7% virologically suppressed. Comorbid conditions were hepatitis B or C (74.4%), smoking (67.4%), chronic obstructive pulmonary disease (30.2%), asthma (14%), and obesity (8.6%). Seven patients had received seasonal influenza vaccination, and 2 the H1N1 vaccine. Cough (100%), fever (93%), gastrointestinal disorders (27.9%) or general--myalgia, general malaise--(67.4%) were the presenting symptoms. These were severe in 24 (55.8%) with 7 (16.3%) requiring intensive care. Two patients died. A lower CD4 lymphocyte count was associated with bacterial infection (P=.063) and longer hospital stay (P=.007). Early oseltamivir reduced severe cases (OR, 4.5; 1.1-18.3; P=.035). CONCLUSIONS: HIV-infected patients admitted to hospital due to influenza A H1N1 had severe morbidity. Low CD4 lymphocytes correlated with longer hospitalization and bacterial infections. Early oseltamivir treatment reduced severe symptoms.
PURPOSE: To determine the clinical, epidemiological and prognostic factors of HIV-infectedpatients with influenza A H1N1 admitted to hospital. METHODS: The study population was HIV infectedpatients with confirmed influenza infection admitted to hospital in a multicenter cohort. We analyzed demographic data, comorbid conditions, severe events (bronchopneumonia, respiratory insufficiency, respiratory distress, sepsis, admission to intensive care unit, death) and outcome. Data were analyzed using descriptive statistics. Proportions were compared using the χ(2) test or Fisher exact test, when applicable. Quantitative variables were compared using the Student t test or Mann-Whitney test. Prognostic impact was analyzed using logistic regression. RESULTS: A total of 43 patients, of whom 62.8% were male, were included from 22 hospitals. The mean age was 43.3 years (interquartile range [IQR], 38.4-48.4). HIV was diagnosed for a mean of 14.5 years (IQR, 8.4-20.3). CD4 lymphocyte was <200 cells/μL in 38%; 85.7% were on antiretroviral therapy, and 66.7% virologically suppressed. Comorbid conditions were hepatitis B or C (74.4%), smoking (67.4%), chronic obstructive pulmonary disease (30.2%), asthma (14%), and obesity (8.6%). Seven patients had received seasonal influenza vaccination, and 2 the H1N1 vaccine. Cough (100%), fever (93%), gastrointestinal disorders (27.9%) or general--myalgia, general malaise--(67.4%) were the presenting symptoms. These were severe in 24 (55.8%) with 7 (16.3%) requiring intensive care. Two patients died. A lower CD4 lymphocyte count was associated with bacterial infection (P=.063) and longer hospital stay (P=.007). Early oseltamivir reduced severe cases (OR, 4.5; 1.1-18.3; P=.035). CONCLUSIONS:HIV-infectedpatients admitted to hospital due to influenza A H1N1 had severe morbidity. Low CD4 lymphocytes correlated with longer hospitalization and bacterial infections. Early oseltamivir treatment reduced severe symptoms.
Authors: Francisco Álvarez-Lerma; Judith Marín-Corral; Clara Vila; Joan Ramón Masclans; Francisco Javier González de Molina; Ignacio Martín Loeches; Sandra Barbadillo; Alejandro Rodríguez Journal: Crit Care Date: 2016-10-23 Impact factor: 9.097
Authors: Cornelia Adlhoch; Joana Gomes Dias; Isabelle Bonmarin; Bruno Hubert; Amparo Larrauri; Jesús A Oliva Domínguez; Concepción Delgado-Sanz; Mia Brytting; Annasara Carnahan; Odette Popovici; Emilia Lupulescu; Joan O'Donnell; Lisa Domegan; Arianne B Van Gageldonk-Lafeber; Adam Meijer; Jan Kynčl; Pavel Slezák; Raquel Guiomar; Carlos M Orta Gomes; Theresia Popow-Kraupp; Ján Mikas; Edita Staroňová; Jackie M Melillo; Tanya Melillo; Niina Ikonen; Outi Lyytikäinen; René Snacken; Pasi Penttinen Journal: Open Forum Infect Dis Date: 2019-10-29 Impact factor: 3.835
Authors: A C Pecego; R T Amâncio; D M Costa; F A Bozza; M M Siqueira; M L Oliveira; J Cerbino-Neto; A Japiassu Journal: Int J STD AIDS Date: 2020-01-22 Impact factor: 1.359