| Literature DB >> 22459051 |
Mahnaz Bayat1, Tourandokht Baluchnejadmojarad, Mehrdad Roghani, Fatemeh Goshadrou, Abdolaziz Ronaghi, Mehdi Mehdizadeh.
Abstract
Cerebral ischemia, which is the second and most common cause of mortality, affects millions of individuals worldwide. The present study was performed to investigate whether intrahippocampal administration of netrin-1 could improve spatial memory impairment in radial arm maze task and restore long-term potentiation (LTP) in 4-vessel occlusion model of global ischemia. The results showed that intrahippocampal infusion of nerin-1 24 h after ischemia (at both doses of 400 and 800 ng) significantly ameliorated spatial memory impairment and at a dose of 800 ng was capable to improve synaptic dysfunction as observed by recovery of population spike component of basal evoked potential and LTP through enhancement of excitability and normalization of paired pulse response. Taken together, the present study shows that netrin-1 dose-dependently ameliorates spatial memory impairment and improves synaptic dysfunction as observed by recovery of population spike component of basal evoked potential and LTP in rats with global ischemia.Entities:
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Year: 2012 PMID： 22459051 DOI： 10.1016/j.brainres.2012.03.008
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252