Enhanced adsorption of paracetamol on closed carbon nanotubes by formation of nanoaggregates: carbon nanotubes as potential materials in hot-melt drug deposition-experiment and simulation.

We present the new results of systematic studies of paracetamol adsorption on closed, commercially available, unmodified carbon nanotubes. The results of thermal analysis, static adsorption measurements and the comparison with phenol adsorption data lead to suggestion that the formation of paracetamol nanoaggregates in the interstitial spaces between nanotubes occurs. This effect is also confirmed by the results of (performed in two ways) independent dynamic measurements and by molecular dynamics simulation technique. Next, we show that the behavior of adsorbed paracetamol during heating leads to the creation of a new drug delivery system. The properties of this system depend on the type of applied nanotubes and the parameters of the process called hot-melt drug deposition. Thus, we conclude that confined nanoaggregate formation, as well as hot-melt deposition should be promising effects in the preparation of highly effective, new drug delivery systems.