| Literature DB >> 22459010 |
Irina Rudneva1, Anna Ignatieva, Tatiana Timofeeva, Aleksandr Shilov, Alla Kushch, Olga Masalova, Regina Klimova, Nicolai Bovin, Larisa Mochalova, Nikolai Kaverin.
Abstract
A panel of 6 neutralizing monoclonal antibodies (MAbs) raised against A/Moscow/IIV01/2009 (H1N1) virus isolated during the 2009 pandemic was used for the selection of 26 escape mutants. The mutants were characterized in immune cross-reactions with the panel of MAbs. The sequencing of the mutant HA genes revealed 5 amino acid positions recognized by monoclonal antibodies: 129, 156, 158, 159, and 190 (H3 numbering). The amino acid positions were distributed in two epitopes belonging to antigenic sites Sa and Sb. The mutant HAs exhibited variations in the affinity to synthetic high molecular mass sialic acid-containing receptor analogues. Results are discussed in connection with the antigenic drift potential of the "swine-like" pandemic 2009 influenza virus.Entities:
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Year: 2012 PMID： 22459010 DOI： 10.1016/j.virusres.2012.03.003
Source DB: PubMed Journal: Virus Res ISSN： 0168-1702 Impact factor: 3.303