AIM: The present study aimed to examine whether plasma osteopontin (pOPN) and symmetric dimethylarginine (pSDMA) are useful biomarkers of renal dysfunction in children with solitary functioning kidney (SFK). METHODS: We measured circulating pOPN and pSDMA in 51 patients with SFK and no other urinary defects. Patients were subdivided into two groups: primary SFK (pSFK) - unilateral renal agenesis (URA), and secondary SFK (sSFK) - unilateral nephrectomy. The control group (C) contained 21 healthy children, with mean age 9.92 ± 4.85 years. Immunoenzymatic ELISA commercial kits were used to measure pOPN and pSDMA concentrations. RESULTS: Plasma osteopontin and pSDMA levels in children with SFK were higher than those in healthy participants (p < 0.05). There was no difference in pOPN and pSDMA concentrations between patients with pSFK and those with sSFK (p > 0.05). Receiver operator characteristic analyses performed to define the diagnostic efficiency of serum creatinine, pOPN and pSDMA in identifying children with C(cr) < 90 mL/min/1.73 m(2) among all examined children revealed no differences between all three AUCs (p > 0.05). CONCLUSION: Increased pOPN and pSDMA levels were observed in children with SFK. Both pOPN and pSDMA correlated with eGFR; however, the sensitivity and specificity of those markers were not better than those of creatinine.
AIM: The present study aimed to examine whether plasma osteopontin (pOPN) and symmetric dimethylarginine (pSDMA) are useful biomarkers of renal dysfunction in children with solitary functioning kidney (SFK). METHODS: We measured circulating pOPN and pSDMA in 51 patients with SFK and no other urinary defects. Patients were subdivided into two groups: primary SFK (pSFK) - unilateral renal agenesis (URA), and secondary SFK (sSFK) - unilateral nephrectomy. The control group (C) contained 21 healthy children, with mean age 9.92 ± 4.85 years. Immunoenzymatic ELISA commercial kits were used to measure pOPN and pSDMA concentrations. RESULTS: Plasma osteopontin and pSDMA levels in children with SFK were higher than those in healthy participants (p < 0.05). There was no difference in pOPN and pSDMA concentrations between patients with pSFK and those with sSFK (p > 0.05). Receiver operator characteristic analyses performed to define the diagnostic efficiency of serum creatinine, pOPN and pSDMA in identifying children with C(cr) < 90 mL/min/1.73 m(2) among all examined children revealed no differences between all three AUCs (p > 0.05). CONCLUSION: Increased pOPN and pSDMA levels were observed in children with SFK. Both pOPN and pSDMA correlated with eGFR; however, the sensitivity and specificity of those markers were not better than those of creatinine.
Authors: Zoe McArdle; Reetu R Singh; Helle Bielefeldt-Ohmann; Karen M Moritz; Michiel F Schreuder; Kate M Denton Journal: J Am Soc Nephrol Date: 2022-03-29 Impact factor: 14.978
Authors: Akram E El-Sadek; Eman G Behery; Ahmed A Azab; Naglaa M Kamal; Mostafa A Salama; Waleed E Abdulghany; Enas A A Abdallah Journal: Ann Med Surg (Lond) Date: 2016-06-02