Fadi Brimo1, Jonathan I Epstein. 1. Departments of Pathology and Urology, McGill University Health Center, Montréal, Quebec, Canada.
Abstract
CONTEXT: Several common differential diagnoses are encountered in urologic pathology, frequently causing patient referrals for a second opinion. OBJECTIVES: To review 3 common differential diagnoses encountered in a large consultation service in genitourinary pathology, including partial atrophy versus prostatic acinar adenocarcinoma, oncocytoma versus chromophobe renal cell carcinoma, and urothelial carcinoma in situ versus normal urothelium and reactive atypia. We will discuss the detailed, morphologically distinctive features and the usefulness of immunohistochemistry. DATA SOURCES: Personal experience and review of the current literature. CONCLUSIONS: Careful morphologic assessment and awareness of diagnostic pitfalls are fundamental in reaching a definitive diagnosis in most cases. Immunohistochemistry is useful but should be used only in conjunction with the morphologic impression.
CONTEXT: Several common differential diagnoses are encountered in urologic pathology, frequently causing patient referrals for a second opinion. OBJECTIVES: To review 3 common differential diagnoses encountered in a large consultation service in genitourinary pathology, including partial atrophy versus prostatic acinar adenocarcinoma, oncocytoma versus chromophobe renal cell carcinoma, and urothelial carcinoma in situ versus normal urothelium and reactive atypia. We will discuss the detailed, morphologically distinctive features and the usefulness of immunohistochemistry. DATA SOURCES: Personal experience and review of the current literature. CONCLUSIONS: Careful morphologic assessment and awareness of diagnostic pitfalls are fundamental in reaching a definitive diagnosis in most cases. Immunohistochemistry is useful but should be used only in conjunction with the morphologic impression.
Authors: Ana Sílvia Pires-Luís; Márcia Vieira-Coimbra; Filipa Quintela Vieira; Pedro Costa-Pinheiro; Rui Silva-Santos; Paula C Dias; Luís Antunes; Francisco Lobo; Jorge Oliveira; Céline S Gonçalves; Bruno M Costa; Rui Henrique; Carmen Jerónimo Journal: Epigenetics Date: 2015 Impact factor: 4.528
Authors: P J Zondervan; P G K Wagstaff; M M Desai; D M de Bruin; A F Fraga; B A Hadaschik; J Köllermann; U B Liehr; S A Pahernik; H P Schlemmer; J J Wendler; F Algaba; J J M C H de la Rosette; M P Laguna Pes Journal: World J Urol Date: 2016-04-22 Impact factor: 4.226