Literature DB >> 2245874

Insulin-mimicking anti-idiotypic antibodies in development of spontaneous autoimmune diabetes in BB/E rats.

D Elias1, A J Bone, J D Baird, A Cooke, I R Cohen.   

Abstract

BB/E rats spontaneously develop a form of autoimmune diabetes resembling insulin-dependent diabetes mellitus (IDDM) in humans. IDDM results from central destruction of the insulin-producing beta-cells of the pancreatic islets. Herein, we report that the outbreak of IDDM in BB/E rats is preceded by the spontaneous development of an anti-idiotypic antibody to a particular antibody to insulin made by the rats. This anti-idiotype, designated anti-DM-id, behaves as an antibody to the insulin-hormone receptor. Thus, a spontaneous anti-idiotypic antibody network whose products can affect the peripheral utilization of insulin seems to accompany the central destruction of beta-cells in developing IDDM.

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Year:  1990        PMID： 2245874     DOI： 10.2337/diab.39.12.1467

Source DB:  PubMed          Journal:  Diabetes        ISSN： 0012-1797            Impact factor:   9.461


  5 in total

Review 1.  Protective role of anti-idiotypic antibodies in autoimmunity--lessons for type 1 diabetes.

Authors:  Christiane S Hampe
Journal:  Autoimmunity       Date:  2012-02-23       Impact factor: 2.815

2.  Linoleic acid metabolism in the spontaneously diabetic rat: delta6-desaturase activity vs. product/precursor ratios.

Authors:  J E Brown; R M Lindsay; R A Riemersma
Journal:  Lipids       Date:  2000-12       Impact factor: 1.880

3.  DNA vaccine containing the mycobacterial hsp65 gene prevented insulitis in MLD-STZ diabetes.

Authors:  Rubens R Santos; Alexandrina Sartori; Deison S Lima; Patrícia Rm Souza; Arlete Am Coelho-Castelo; Vânia Ld Bonato; Célio L Silva
Journal:  J Immune Based Ther Vaccines       Date:  2009-09-15

4.  Modulation of diabetes in NOD mice by GAD65-specific monoclonal antibodies is epitope specific and accompanied by anti-idiotypic antibodies.

Authors:  Tyler R Hall; Marika Bogdani; Renee C Leboeuf; Elizabeth A Kirk; Marlena Maziarz; J Paul Banga; Shilpa Oak; Christina A Pennington; Christiane S Hampe
Journal:  Immunology       Date:  2007-11-14       Impact factor: 7.397

5.  The lack of anti-idiotypic antibodies, not the presence of the corresponding autoantibodies to glutamate decarboxylase, defines type 1 diabetes.

Authors:  Shilpa Oak; Lisa K Gilliam; Mona Landin-Olsson; Carina Törn; Ingrid Kockum; Christina R Pennington; Merrill J Rowley; Michael R Christie; J Paul Banga; Christiane S Hampe
Journal:  Proc Natl Acad Sci U S A       Date:  2008-03-26       Impact factor: 11.205
  5 in total

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