Literature DB >> 22457282

Latent acyclovir-resistant herpes simplex virus type 1 in trigeminal ganglia of immunocompetent individuals.

Monique van Velzen1, Freek B van Loenen, Roland J W Meesters, Miranda de Graaf, Lies Remeijer, Theo M Luider, Albert D M E Osterhaus, Georges M G M Verjans.   

Abstract

Specific mutations within the hypervariable herpes simplex virus (HSV) gene thymidine kinase (TK) gene lead to acyclovir (ACV) resistance. To uncover the existence of latent ACV-resistant (ACV(R)) HSV-1, we determined the genetic and functional variability of the HSV-1 TK gene pool in paired trigeminal ganglia (TG) of 5 immunocompetent individuals. The latent virus pool consisted of a donor-specific HSV-1 quasispecies, including one major ACV-sensitive (ACV(S)) and multiple phylogenetic-related minor ACV(S) and ACV(R) TK variants. Contrary to minor variants, major TK variants were shared between paired TG. The data demonstrate the coexistence of phylogenetic-related ACV(S) and ACV(R) latent HSV-1 in human TG.

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Year:  2012        PMID： 22457282     DOI： 10.1093/infdis/jis237

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  14 in total

1.  Highly conserved intragenic HSV-2 sequences: Results from next-generation sequencing of HSV-2 UL and US regions from genital swabs collected from 3 continents.

Authors:  Christine Johnston; Amalia Magaret; Pavitra Roychoudhury; Alexander L Greninger; Anqi Cheng; Kurt Diem; Matthew P Fitzgibbon; Meei-Li Huang; Stacy Selke; Jairam R Lingappa; Connie Celum; Keith R Jerome; Anna Wald; David M Koelle
Journal:  Virology       Date:  2017-07-13       Impact factor: 3.616

2.  Antiherpes simplex virus type 2 activity of the antimicrobial peptide subtilosin.

Authors:  V M Quintana; N I Torres; M B Wachsman; P J Sinko; V Castilla; M Chikindas
Journal:  J Appl Microbiol       Date:  2014-08-23       Impact factor: 3.772

3.  Safety, formulation, and in vitro antiviral activity of the antimicrobial peptide subtilosin against herpes simplex virus type 1.

Authors:  Nicolás I Torres; Katia Sutyak Noll; Shiqi Xu; Ji Li; Qingrong Huang; Patrick J Sinko; Mónica B Wachsman; Michael L Chikindas
Journal:  Probiotics Antimicrob Proteins       Date:  2013-03-01       Impact factor: 4.609

4.  Common and new acyclovir resistant herpes simplex virus-1 mutants causing bilateral recurrent herpetic keratitis in an immunocompetent patient.

Authors:  Dongli Pan; Stephen B Kaye; Mark Hopkins; Ruaidhri Kirwan; Ian J Hart; Donald M Coen
Journal:  J Infect Dis       Date:  2013-08-14       Impact factor: 5.226

5.  Longitudinal study on oral shedding of herpes simplex virus 1 and varicella-zoster virus in individuals infected with HIV.

Authors:  Monique van Velzen; Werner J D Ouwendijk; Stacy Selke; Suzan D Pas; Freek B van Loenen; Albert D M E Osterhaus; Anna Wald; Georges M G M Verjans
Journal:  J Med Virol       Date:  2013-06-18       Impact factor: 2.327

6.  Silencing herpes simplex virus type 1 capsid protein encoding genes by siRNA: a promising antiviral therapeutic approach.

Authors:  Fujun Jin; Shen Li; Kai Zheng; Cuiqin Zhuo; Kaiqi Ma; Maoyun Chen; Qiaoli Wang; Peizhuo Zhang; Jianglin Fan; Zhe Ren; Yifei Wang
Journal:  PLoS One       Date:  2014-05-02       Impact factor: 3.240

7.  Prevalence of Intrathecal Acyclovir Resistant Virus in Herpes Simplex Encephalitis Patients.

Authors:  Johanna G Mitterreiter; Maarten J Titulaer; Gijsbert P van Nierop; Jeroen J A van Kampen; Georgina I Aron; Albert D M E Osterhaus; Georges M G M Verjans; Werner J D Ouwendijk
Journal:  PLoS One       Date:  2016-05-12       Impact factor: 3.240

Review 8.  Herpes Simplex Virus: A Versatile Tool for Insights Into Evolution, Gene Delivery, and Tumor Immunotherapy.

Authors:  Prapti H Mody; Sushila Pathak; Laura K Hanson; Juliet V Spencer
Journal:  Virology (Auckl)       Date:  2020-05-29

9.  Targeting herpetic keratitis by gene therapy.

Authors:  Hossein Mostafa Elbadawy; Marine Gailledrat; Carole Desseaux; Diego Ponzin; Stefano Ferrari
Journal:  J Ophthalmol       Date:  2012-12-26       Impact factor: 1.909

10.  Genetic variation of human papillomavirus type 16 in individual clinical specimens revealed by deep sequencing.

Authors:  Iwao Kukimoto; Tomohiko Maehama; Tsuyoshi Sekizuka; Yumiko Ogasawara; Kazunari Kondo; Rika Kusumoto-Matsuo; Seiichiro Mori; Yoshiyuki Ishii; Takamasa Takeuchi; Toshiyuki Yamaji; Fumihiko Takeuchi; Kentaro Hanada; Makoto Kuroda
Journal:  PLoS One       Date:  2013-11-13       Impact factor: 3.240
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