Review of the phytochemical, pharmacological and toxicological properties of Alstonia Scholaris Linn. R. Br (Saptaparna).

The use of ethnornedical information has immensely contributed to health care, and scientific studies have shown that the evaluation of traditionally used medicines may provide leads towards effective drug discovery. Since antiquity, Alstonia scholaris connmonly known as devil's tree has been used for the treatment of many human ailments. Literature suggests that Alstonia scholaris is useful in treating malaria, abdominal disorders, dyspepsia, leprosy, skin diseases, tumors, chronic and foul ulcers, asthma, bronchitis, helminthiasis, agalactia, and debility. Preclinical studies have shown that it possesses anti-microbial, anti-diarrhoeal, anti-plasmodial, anti-oxidant, anti-inflammatory hepatoprotective, nootrophic, anti-stress, anti-fertility, immunomodulatory, analgesic, anti-ulcer, wound healing, anti-cancer, chemopreventive, radiation protection, radiation sensitization, and chemosensitization activities. The diverse pharmacological observations are supposed to be due to the presence of alkaloids, flavonoids and phenolic acids. The bark and leaf extract when administered orally did not induce lethality or adverse affects at the limit doses of 2 000 mg/kg body weight. However when administered intraperitoneally at high concentrations, the extract showed systemic and developmental toxicities. This review addresses the experimentally authenticated facts and also suggests the need for research on chemical and pharmacological properties of Alstonia scholaris.