Literature DB >> 22455627

Preparation of trifluoromethyl-substituted aziridines with in situ generated CF3CHN2.

Stefan A Künzi1, Bill Morandi, Erick M Carreira.   

Abstract

Direct access to trifluoromethyl-substituted aziridines through the use of a protocol in which trifluoromethyl diazomethane is generated in situ and subsequently undergoes addition to activated imines is reported.

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Year:  2012        PMID： 22455627     DOI： 10.1021/ol300539e

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  6 in total

1.  Base mediated deprotection strategies for trifluoroethyl (TFE) ethers, a new alcohol protecting group.

Authors:  Qingliang Yang; Jon T Njardarson
Journal:  Tetrahedron Lett       Date:  2013-12-18       Impact factor: 2.415

2.  Three-component synthesis of highly functionalized aziridines containing a peptide side chain and their one-step transformation into β-functionalized α-ketoamides.

Authors:  Lena Huck; Juan F González; Elena de la Cuesta; J Carlos Menéndez
Journal:  Beilstein J Org Chem       Date:  2016-08-08       Impact factor: 2.883

3.  A practical and catalyst-free trifluoroethylation reaction of amines using trifluoroacetic acid.

Authors:  Keith G Andrews; Radmila Faizova; Ross M Denton
Journal:  Nat Commun       Date:  2017-06-26       Impact factor: 14.919

4.  Telescoped, Divergent, Chemoselective C1 and C1-C1 Homologation of Imine Surrogates: Access to Quaternary Chloro- and Halomethyl-Trifluoromethyl Aziridines.

Authors:  Laura Ielo; Saad Touqeer; Alexander Roller; Thierry Langer; Wolfgang Holzer; Vittorio Pace
Journal:  Angew Chem Int Ed Engl       Date:  2019-01-24       Impact factor: 15.336

5.  Use of trifluoroacetaldehyde N-tfsylhydrazone as a trifluorodiazoethane surrogate and its synthetic applications.

Authors:  Xinyu Zhang; Zhaohong Liu; Xiangyu Yang; Yuanqing Dong; Matteo Virelli; Giuseppe Zanoni; Edward A Anderson; Xihe Bi
Journal:  Nat Commun       Date:  2019-01-17       Impact factor: 14.919

6.  Asymmetric synthesis of CF2-functionalized aziridines by combined strong Brønsted acid catalysis.

Authors:  Xing-Fa Tan; Fa-Guang Zhang; Jun-An Ma
Journal:  Beilstein J Org Chem       Date:  2020-04-07       Impact factor: 2.883
  6 in total

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