| Literature DB >> 22455453 |
Huangdi Feng1, Denis S Ermolat'ev, Gonghua Song, Erik V Van der Eycken.
Abstract
An efficient and novel copper-mediated protocol for the synthesis of 3-amino-1,4-enynes from glyoxylic acid, an amine, and an alkyne was developed. This new reaction involving two sequential C-C bond formations is air and moisture tolerant and proceeds via a tandem A(3)-coupling and a selective decarboxylative coupling.Entities:
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Year: 2012 PMID： 22455453 DOI： 10.1021/ol3006612
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005