OBJECTIVE: To assay the inhibitory effects of cepharanthine on HSV-1 in vitro. METHODS: Vero cells were infected by HSV-1 and cultured with serial dilutions of cepharanthine. The inhibitory effects of cepharanthine were evaluated with cytopathogenic effects (CPE). RESULTS: The CPE of cells infected by HSV-1 were inhibited significantly, resulting in higher cell survival rates. CONCLUSION: The results showed that cepharanthine had obvious HSV-1 inhibitory efficacy. Therefore, it may become a potential candidate in drug development and deserves further research on animal experiment and antiviral mechanisms.
OBJECTIVE: To assay the inhibitory effects of cepharanthine on HSV-1 in vitro. METHODS: Vero cells were infected by HSV-1 and cultured with serial dilutions of cepharanthine. The inhibitory effects of cepharanthine were evaluated with cytopathogenic effects (CPE). RESULTS: The CPE of cells infected by HSV-1 were inhibited significantly, resulting in higher cell survival rates. CONCLUSION: The results showed that cepharanthine had obvious HSV-1 inhibitory efficacy. Therefore, it may become a potential candidate in drug development and deserves further research on animal experiment and antiviral mechanisms.
Authors: Francesco Monticolo; Emanuela Palomba; Rosa De Santis; Lorenzo Assentato; Viviana Triscino; Maria Chiara Langella; Virginia Lanzotti; Maria Luisa Chiusano Journal: Trends Food Sci Technol Date: 2020-09-22 Impact factor: 12.563
Authors: Dong Eon Kim; Jung Sun Min; Min Seong Jang; Jun Young Lee; Young Sup Shin; Jong Hwan Song; Hyoung Rae Kim; Seungtaek Kim; Young-Hee Jin; Sunoh Kwon Journal: Biomolecules Date: 2019-11-04