| Literature DB >> 2245492 |
R E Coleman1, J M Clarke, M L Slevin, J Sweetenham, C J Williams, P Blake, F Calman, E Wiltshaw, P G Harper.
Abstract
A total of 44 women received a combination of ifosfamide (1.5 g/m2 daily x5) and cisplatin (50 mg/m2 on day 1 only) as first-line chemotherapy for recurrent or metastatic carcinoma of the cervix. In all, 12/42 (38%) evaluable patients responded, with the median duration of response being 7 months. Bone marrow and gastrointestinal toxicity were frequently severe. There were 3 septic deaths. Although cisplatin plus ifosfamide is an active combination against this disease, these results suggest that it is no more so than either drug used alone.Entities:
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Year: 1990 PMID： 2245492 DOI： 10.1007/bf00689276
Source DB: PubMed Journal: Cancer Chemother Pharmacol ISSN： 0344-5704 Impact factor: 3.333