Literature DB >> 22454869

Interaction between debrisoquine and phenylephrine in man.

W Allum1, J Aminu, T H Bloomfield, C Davies, A H Scales, D W Vere.   

Abstract

1 The interaction between phenylephrine and debrisoquine was studied using normal and hypertensive human volunteers, measuring blood pressure, pulse rate and pupil diameter. Single doses of phenylephrine were given before, during and after a short course of debrisoquine treatment. 2 The circulatory effects of phenylephrine are potentiated by debrisoquine; in a few subjects this potentiation was marked and a potential hazard. 3 Limited deductions could be made about the effects of debrisoquine on baroceptor responses and adrenergic mechanisms.

Entities:  

Year:  1974        PMID： 22454869      PMCID： PMC1402409          DOI： 10.1111/j.1365-2125.1974.tb00206.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  9 in total

1.  TREATMENT OF HYPERTENSION WITH DEBRISOQUIN SULFATE (DECLINAX).

Authors:  M H LURIA; E D FREIS
Journal:  Curr Ther Res Clin Exp       Date:  1965-05

2.  The effects of debrisoquin and bretylium on adrenergic nerves as revealed by fluorescence histochemistry.

Authors:  T Malmors; W B Abrams
Journal:  J Pharmacol Exp Ther       Date:  1970-07       Impact factor: 4.030

3.  Diminished baroreflex sensitivity in high blood pressure.

Authors:  J D Bristow; A J Honour; G W Pickering; P Sleight; H S Smyth
Journal:  Circulation       Date:  1969-01       Impact factor: 29.690

4.  Reflex regulation of arterial pressure during sleep in man. A quantitative method of assessing baroreflex sensitivity.

Authors:  H S Smyth; P Sleight; G W Pickering
Journal:  Circ Res       Date:  1969-01       Impact factor: 17.367

Review 5.  Monoamine oxidase inhibitors.

Authors:  A Pletscher
Journal:  Pharmacol Rev       Date:  1966-03       Impact factor: 25.468

6.  Interactions between catecholamines and tricyclic and monoamine oxidase inhibitor antidepressive agents in man.

Authors:  F S Barar; A J Boakes; L B Benedikter; D R Laurence; B N Prichard; P C Teoh
Journal:  Br J Pharmacol       Date:  1971-10       Impact factor: 8.739

7.  The influence of debrisoquin on the accumulation and metabolism of biogenic amines by the human platelet, in vivo and in vitro.

Authors:  H M Solomon; C Ashley; N Spirt; W B Abrams
Journal:  Clin Pharmacol Ther       Date:  1969 Mar-Apr       Impact factor: 6.875

8.  Interaction between debrisoquine and phenylephrine.

Authors:  J Aminu; A D'Mello; D W Vere
Journal:  Lancet       Date:  1970-10-31       Impact factor: 79.321

9.  A comparison of some atropine-like drugs in man, with particular reference to their end-organ specificity.

Authors:  A HERXHEIMER
Journal:  Br J Pharmacol Chemother       Date:  1958-06
  9 in total
  2 in total

Review 1.  Drug interactions that matter. A critical reappraisal.

Authors:  G T McInnes; M J Brodie
Journal:  Drugs       Date:  1988-07       Impact factor: 9.546

2.  The human pupil as a model for clinical pharmacological investigations.

Authors:  P Turner
Journal:  J R Coll Physicians Lond       Date:  1975-01
  2 in total

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