| Literature DB >> 22453965 |
Abstract
Aim of this review is to give an overview and discuss recent findings on the role of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in the heart. Special attention is drawn to excitation-contraction coupling (ECC) and excitation-transcription coupling (ETC). Because CaMKII expression and activity are increased in cardiac hypertrophy, heart failure, and during arrhythmias both in animal models as well as in the human heart a clinical significance of CaMKII is implied.Entities:
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Year: 2012 PMID: 22453965 DOI: 10.1007/978-94-007-2888-2_30
Source DB: PubMed Journal: Adv Exp Med Biol ISSN: 0065-2598 Impact factor: 2.622