| Literature DB >> 2245336 |
D J Skene1, B Vivien-Roels, D L Sparks, J C Hunsaker, P Pévet, D Ravid, D F Swaab.
Abstract
Melatonin and 5-methoxytryptophol (ML) were measured in human pineals (38 controls, 16 subjects with Alzheimer's disease). Time of death had a major influence on the indole concentrations with significantly higher melatonin levels occurring at night (22.00-10.00 h) and significantly higher ML levels occurring during the day (10.00-22.00 h). This daily variation disappeared in both the older subjects (55-92 years) and in the Alzheimer patients (55-89 years).Entities:
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Year: 1990 PMID： 2245336 DOI： 10.1016/0006-8993(90)90214-v
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252