Hemodynamic disturbances and activation of lipid peroxidation in the pathogenesis of acute myocardial injury induced by propranolol in toxic doses.

We studied the dose-dependent cardiotoxic effect of propranolol. Intraperitoneal injection of propranolol in doses of 1 and 2 mg/100 g body weight produced a potent effect on central hemodynamics and myocardial contractility, impaired diastolic relaxation, and caused damage to cardiomyocyte membranes due to activation of free radical oxidation.