| Literature DB >> 22451511 |
Chiara Cencioni1, Maurizio C Capogrossi, Monica Napolitano.
Abstract
We review the pivotal role of the stromal derived factor (SDF)-1 chemokine in tissue ischaemia and how it orchestrates the rapid revascularization of injured, ischaemic, and regenerating tissues via the CXC chemokine receptors CXCR4 and CXCR7. Furthermore, we discuss the effects of preconditioning (PC), which is a well-known protective phenomenon for tissue ischaemia. The positive effect of both hypoxic and acidic PC on progenitor cell therapeutic potential is reviewed, while stressing the role of the SDF-1/CXCR4 axis in this process.Entities:
Mesh:
Substances:
Year: 2012 PMID: 22451511 DOI: 10.1093/cvr/cvs132
Source DB: PubMed Journal: Cardiovasc Res ISSN: 0008-6363 Impact factor: 10.787